Cardiovascular computed tomography for diagnosis and risk stratification of coronary artery disease

Werkhoven, J.M. van (2011)

Doctoral Thesis

Non-invasive imaging plays an increasingly important role in the diagnosis and risk stratification of coronary artery disease. Several techniques such as stress echocardiography and myocardial perfusion imaging have become available to assess cardiac function and myocardial perfusion. With the arrival of multi-slice computed tomography coronary angiography (CTA), non-invasive imaging of coronary anatomy has also become possible. CTA is a relatively new imaging technique; the objective of the thesis is therefore to explore the value of CTA for diagnosis and risk stratification of CAD in patients presenting with suspected and known CAD, in order to further define its role in clinical practice. The results of this thesis show that CTA provides important diagnostic information relative to existing non-invasive imaging strategies. In addition the detailed anatomic information obtained using CTA was shown to provide important prognostic information. CTA supplies complementary information to existing non-invasive imaging techniques, and has the potential to provide a more patient tailored approach to patient management. What remains to be determined is how CTA and non-invasive functional imaging should be integrated into clinical practice.

• Coronary angiography
• Risk Stratification
• Diagnosis
• Imaging
• Atherosclerosis
• Coronary Artery Disease
• Cardiovascular Computed Tomography

• All authors: Werkhoven, J.M. van
• Supervisor: Bax, J.J.; Jukema, J.W.; Roos, A. de
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2011-06-23
• Sponsorship: Nederlandse Vereniging voor Cardiologie Interuniversitair Cardiologisch Instituut Nederland