Diabetic nephropathy in Surinamese South Asian subjects

Chandieshaw, P.K. (2008)

Doctoral Thesis

This thesis focuses on the incidence and risk factors for nephropathy in diabetic and non-diabetic Surinamese South Asians. The Surinamese South Asians, originally descended from the North-East India. Due to the former colonial bounds with the Netherlands, a relatively young South Asian migrant population settled in the Netherlands. South Asians have a high prevalence of central obesity and an eight-fold higher prevalence for type 2 diabetes mellitus. We found the following conclusions: 1.Surinamese South Asian persons have a nearly 40-fold higher risk for end-stage diabetic nephropathy in comparison to Dutch European persons. 2.There was no familial predisposition for diabetic nephropathy among South Asian families. 3.South Asian type 2 diabetic patients have a three-fold higher risk for diabetic nephropathy and faster progression of renal insufficiency in comparison to Dutch European patients. 4.Central obesity is an early and independent risk factor for increased albuminuria in normoglycemic South Asian subjects. We assume that the nearly 40-fold higher risk of end-stage diabetic nephropathy in South Asian migrants is primarily caused by central obesity which leads to: a. Early renal injury in the pre-diabetic state. b. Eight-times higher prevalence of type 2 diabetes mellitus. b. More diabetic nephropathy and faster decline in renal function.

• Albuminuria
• Ethnicity
• South Asian
• Asian
• Indian
• Obesity
• Metabolic syndrome
• Insulin resistance
• Epidemiology
• Family studies

• All authors: Chandieshaw, P.K.
• Supervisor: Rabelink, A.B.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2008-03-06
• ISBN (print): 9789090227702
• Sponsorship: Medical Center Haaglanden, Dutch Kidney Foundation Dutch Diabetes Research Foundation.