Purpose: Dental calculus forms on teeth during the life of an individual and its investigation can yield information about diet, health status, and environmental pollution. Currently, the... Show morePurpose: Dental calculus forms on teeth during the life of an individual and its investigation can yield information about diet, health status, and environmental pollution. Currently, the analytical techniques used to visualize the internal structure of human dental calculus and entrapped inclusions are limited and require destructive sampling, which cannot always be justified.Approach: We used propagation phase-contrast synchrotron radiation micro-computed tomography (PPC-SR-μCT) to non-destructively examine the internal organization of dental calculus, including its microstructure and entrapped inclusions, on both modern and archeological samples.Results: The virtual histological exploration of the samples shows that PPC-SR-μCT is a powerful approach to visualize the internal organization of dental calculus. We identified several important features, including previously undetected negative imprints of enamel and dentine growth markers (perikymata and periradicular bands, respectively), the non-contiguous structure of calculus layers with multiple voids, and entrapped plant remains.Conclusions: PPC-SR-μCT is an effective technique to explore dental calculus structural organization, and is especially powerful for enabling the identification of inclusions. The non-destructive nature of synchrotron tomography helps protect samples for future research. However, the irregular layers and frequent voids reveal a high heterogeneity and variability within calculus, with implications for research focusing on inclusions. Show less
Stiphout, J.A. van; Driessen, J.; Koetzier, L.R.; Ruules, L.B.; Willemink, M.J.; Heemskerk, J.W.T.; Molen, A.J. van der 2021
Objective To determine the difference in CT values and image quality of abdominal CT images reconstructed by filtered back-projection (FBP), hybrid iterative reconstruction (IR), and deep learning... Show moreObjective To determine the difference in CT values and image quality of abdominal CT images reconstructed by filtered back-projection (FBP), hybrid iterative reconstruction (IR), and deep learning reconstruction (DLR). Methods PubMed and Embase were systematically searched for articles regarding CT densitometry in the abdomen and the image reconstruction techniques FBP, hybrid IR, and DLR. Mean differences in CT values between reconstruction techniques were analyzed. A comparison between signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of FBP, hybrid IR, and DLR was made. A comparison of diagnostic confidence between hybrid IR and DLR was made. Results Sixteen articles were included, six being suitable for meta-analysis. In the liver, the mean difference between hybrid IR and DLR was - 0.633 HU (p = 0.483, SD +/- 0.902 HU). In the spleen, the mean difference between hybrid IR and DLR was - 0.099 HU (p = 0.925, SD +/- 1.061 HU). In the pancreas, the mean difference between hybrid IR and DLR was - 1.372 HU (p = 0.353, SD +/- 1.476 HU). In 14 articles, CNR was described. In all cases, DLR showed a significantly higher CNR. In 9 articles, SNR was described. In all cases but one, DLR showed a significantly higher SNR. In all cases, DLR showed a significantly higher diagnostic confidence. Conclusions There were no significant differences in CT values reconstructed by FBP, hybrid IR, and DLR in abdominal organs. This shows that these reconstruction techniques are consistent in reconstructing CT values. DLR images showed a significantly higher SNR and CNR, compared to FBP and hybrid IR. Show less
Objectives To report the variation in computed tomography perfusion (CTP) arterial input function (AIF) in a multicenter stroke study and to assess the impact this has on CTP results. Methods CTP... Show moreObjectives To report the variation in computed tomography perfusion (CTP) arterial input function (AIF) in a multicenter stroke study and to assess the impact this has on CTP results. Methods CTP datasets from 14 different centers were included from the DUtch acute STroke (DUST) study. The AIF was taken as a direct measure to characterize contrast bolus injection. Statistical analysis was applied to evaluate differences in amplitude, area under the curve (AUC), bolus arrival time (BAT), and time to peak (TTP). To assess the clinical relevance of differences in AIF, CTP acquisitions were simulated with a realistic anthropomorphic digital phantom. Perfusion parameters were extracted by CTP analysis using commercial software (IntelliSpace Portal (ISP), version 10.1) as well as an in-house method based on block-circulant singular value decomposition (bSVD). Results A total of 1422 CTP datasets were included, ranging from 6 to 322 included patients per center. The measured values of the parameters used to characterize the AIF differed significantly with approximate interquartile ranges of 200-750 HU for the amplitude, 2500-10,000 HU center dot s for the AUC, 0-17 s for the BAT, and 10-26 s for the TTP. Mean infarct volumes of the phantom were significantly different between centers for both methods of perfusion analysis. Conclusions Although guidelines for the acquisition protocol are often provided for centers participating in a multicenter study, contrast medium injection protocols still vary. The resulting volumetric differences in infarct core and penumbra may impact clinical decision making in stroke diagnosis. Show less
This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.The formation mechanism of these toroidal plasmas is identified and an... Show moreThis dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.The formation mechanism of these toroidal plasmas is identified and an estimate of their main plasma parameters is obtained. Furthermore, preliminary experiments are presented, aimed at heating these plasmas by absorption of microwave radiation, in order to counteract their transient nature.Through a tomographic reconstruction, cross-sectional images of the toroidal plasma are obtained, visualising the fluid flow responsible for the generation of the toroidal structure. The origin of the flow is traced back to the structure of the plasma kernel. The shocks generated by this kernel interact akin to a Mach reflection and generate a low pressure region whose replenishment transforms the plasma into a toroid. Schlieren imaging, complemented with a novel scanning-probe technique, and thermodynamic modelling, as well as deliberately breaking the flow symmetry, confirm the formation mechanism. A high-power, sub-microsecond rise time, pulsed magnetron source has been designed for the microwave heating experiments. Its detailed design and the effect of the microwave pulse on the plasma are discussed.This work is part of a larger study on self-organising knotted magnetic structures in plasma, which may find their application in nuclear fusion and astrophysical research. Show less
Speelman, E.S.; Brocx, B.; Wilbers, J.E.; Bie, M.J. de; Ivashchenko, O.; Tank, Y.; Molen, A.J. van der 2019
Purpose Whole-body computed tomography (WBCT) is the standard diagnostic method for evaluating polytrauma patients. When patients are unable to elevate their arms, the arms are placed along the... Show morePurpose Whole-body computed tomography (WBCT) is the standard diagnostic method for evaluating polytrauma patients. When patients are unable to elevate their arms, the arms are placed along the body, which affects the image quality negatively. Aim of this systematic review is to evaluate the influence of below the shoulder arm positions on image quality of WBCT. Methods Literature in PubMed and Scopus databases was systematically searched. Results of the papers were stratified into 4 categories: arms elevated, 1 arm up 1 arm down, arms ventrally supported, arms along the body. A qualitative analysis was performed on subjective image quality and a quantitative analysis on objective quality (image noise). Results Eight studies were included with 1421 participants. Various studies reported significantly higher quality scores with arms elevated, compared to arms along the body. Significant differences in objective image quality were found between the arms elevated and the arms ventrally on support group. The arms ventrally supported group had a significantly higher image quality than the arms along the body group. A statistically significant difference was found in objective image quality between the 1 arm up 1 arm down and arms along the body group. No preferential below the shoulders position could be identified. Conclusion Positioning the arms alongside the body results in a poor image quality. Placing the arms on a pillow ventrally to the chest improves image quality. Interestingly, asymmetrical arm positioning has potential to improve the image quality for patients that are unable to elevate the arms. Show less
Pelgrim, J.; Nieuwenhuis, E.R.; Duguay, T.M.; Geest, R.J. van der; Varga-Szemes, A.; Slump, C.H.; ... ; Vliegenthart, R. 2017
In X-ray tomography, a three-dimensional image of the interior of an object is computed from multiple X-ray images, acquired over a range of angles. Two types of methods are commonly used to... Show moreIn X-ray tomography, a three-dimensional image of the interior of an object is computed from multiple X-ray images, acquired over a range of angles. Two types of methods are commonly used to compute such an image: analytical methods and iterative methods. Analytical methods are computationally efficient, but in many applications, they produce reconstructions that are not accurate enough for further analysis. More accurate reconstructions can be obtained by using (regularized) iterative methods, but these can have computational costs that are too high to be used in practice. In this thesis, new reconstruction methods are developed that combine the analytical and algebraic approaches, resulting in methods that are as computationally efficient as analytical methods, but with a reconstruction accuracy of iterative methods. Analytical methods allow for changing their filter without increasing the needed computation time. We use this freedom in filter choice to develop new filter-based reconstruction methods, which are based on the analytical FBP method with specific filters. The filters can be defined and computed in different ways, and can depend on the acquisition geometry, the scanned object, and/or a separate pre-computing step. Several filter-based methods are introduced in this thesis and reconstruction results are compared with other popular methods. Show less
Bleichrodt, F.; Leeuwen, T. van; Palenstijn, W.J.; Aarle, W. van; Sijbers, J.; Batenburg, K.J. 2016
Mathematical scripting languages are commonly used to develop new tomographic reconstruction algorithms. For large experimental datasets, high performance parallel (GPU) implementations are... Show moreMathematical scripting languages are commonly used to develop new tomographic reconstruction algorithms. For large experimental datasets, high performance parallel (GPU) implementations are essential, requiring a re-implementation of the algorithm using a language that is closer to the computing hardware. In this paper, we introduce a new MATLAB interface to the ASTRA toolbox, a high performance toolbox for building tomographic reconstruction algorithms. By exposing the ASTRA linear tomography operators through a standard MATLAB matrix syntax, existing and new reconstruction algorithms implemented in MATLAB can now be applied directly to large experimental datasets. This is achieved by using the Spot toolbox, which wraps external code for linear operations into MATLAB objects that can be used as matrices. We provide a series of examples that demonstrate how this Spot operator can be used in combination with existing algorithms implemented in MATLAB and how it can be used for rapid development of new algorithms, resulting in direct applicability to large-scale experimental datasets. Show less
We first investigate the microscopic working principle of the nanowire superconducting single-photon detectors (SSPDs), and we find that the edge of the nanowire is much more sensitive than the... Show moreWe first investigate the microscopic working principle of the nanowire superconducting single-photon detectors (SSPDs), and we find that the edge of the nanowire is much more sensitive than the central part. The experimental results agree quantitatively with the theory based on a photon-assisted vertex- entry model. We then explore its potential to be used as a probe for near-field detection. Our calculations show that the SSPDs have a much higher signal collection efficiency than the conventional near-field optical microscopy, and that their spacial resolution can reach 20 nm. With photon number resolving ability, a SSPD fabricated on a micro-pillar can be used to investigate the quantum information of the optical near-field at subwavelength scales. Show less
Part 1: We studied the interaction of light with various devices made from nanoslits in metal: a quarter-wave retarder, a spin-to-orbital angular momentum converter, and a vortex analyzer. Part 2:... Show morePart 1: We studied the interaction of light with various devices made from nanoslits in metal: a quarter-wave retarder, a spin-to-orbital angular momentum converter, and a vortex analyzer. Part 2: We demonstrate anomalous dispersion of surface plasmons on an aluminum surface. Show less
Molen, A.J. van der; Joemai, R.M.S.; Geleijns, J. 2012
In this thesis several aspects on the diagnosing and management of patients with acute abdominal pain are investigated. 1; The efficacy and safety of standard outpatient re-evaluation for patients... Show moreIn this thesis several aspects on the diagnosing and management of patients with acute abdominal pain are investigated. 1; The efficacy and safety of standard outpatient re-evaluation for patients not admitted to the hospital after emergency department evaluation for acute abdominal pain. 2; The use of a diagnostic strategy for patients clinically suspected to have appendicitis incorporating non-invasive modalities such as clinical evaluation, routine ultrasound and clinical re-evaluation, and a minimal use of complementary CT or laparoscopy. 3; The possibility to clinically differentiate between children with acute appendicitis and those with acute mesenteric lymphadenitis. 4; The value of secondary signs during the ultrasonographic evaluation of children with suspected appendicitis. 5; The impact of radiological imaging on diagnostic accuracy and clinical decision making for patients with acute colonic diverticulitis. 6; A systematic review on laparoscopic peritoneal lavage for patients with peritonitis due to perforated colonic diverticulitis. Show less
