In this thesis, determinants, risk and protective factors of parental reactions to childhood cancer are described and research areas that are understudied until now have been identified. Chapter 2... Show moreIn this thesis, determinants, risk and protective factors of parental reactions to childhood cancer are described and research areas that are understudied until now have been identified. Chapter 2 contains a review study on stress and adaptation in parents of pediatric cancer patients. Chapter 3 describes the results of a multicenter study among parents of children with cancer with the aim to evaluate the psychometric qualities of the Dutch version of a disease-related instrument measuring parental stress. Chapter 4 is a review article on parental stress and adaptation among parents of children undergoing stem cell transplantation (SCT). Chapter 5 contains the results of a longitudinal study on child- and parent reported health related quality of life and parenting stress in parents of children undergoing SCT. In Chapter 6, the results of a cross-sectional study on parental stress and perceptions of child vulnerability in parents of children who underwent SCT either 5 or 10 years ago are reported. In Chapter 7, cognitive problems, behavior problems and health related quality of life of children with LCH are described. Show less