Leprosy is a multifactorial chronic disease caused by Mycobacterium leprae or Mycobacterium lepromatosis that affects the skin and nerves. More than 200.000 new cases are diagnosed per year; thus,... Show moreLeprosy is a multifactorial chronic disease caused by Mycobacterium leprae or Mycobacterium lepromatosis that affects the skin and nerves. More than 200.000 new cases are diagnosed per year; thus, transmission is still ongoing. The most likely way of transmission is the respiratory route form human-to-human; however, transmission is still not clearly understood. Early diagnosis of leprosy is crucial to reduce and avoid transmission as well as leprosy-associated disabilities, which are also a cause of stigma. Currently, diagnosis is performed based on clinical signs and symptoms and late- or mis-diagnosis are not uncommon.In this thesis, we combined the study of pathogen transmission with host transcriptomic and genomic biomarkers. To explore M. leprae transmission a One Health approach was followed, where human, animal and environmental samples were studied.The combination of demographic characteristics, pathogen detection, genetic and/or transcriptomic biomarkers can be applied in a multifactorial leprosy signature applicable for early diagnosis of leprosy and/or to guide intervention strategies. Identification of predictive biomarkers will in due course lead to prompt treatment, preventing leprosy-associated irreversible disabilities as well as reducing M. leprae transmission. Show less
One Health calls for cross-disciplinary collaboration in health policy out of a recognition of interdependency between human and non-human animal health against the backdrop of ecological... Show moreOne Health calls for cross-disciplinary collaboration in health policy out of a recognition of interdependency between human and non-human animal health against the backdrop of ecological processes. As a new perspective on health policy, it lacks sufficient engagement with justice. A moral right to health is proposed as a means to instill justice in One Health thought and practice. This act itself prompts a reevaluation of such a moral right from both an ecological and interspecies perspective. The thesis follows up on the Great Ape Project (GAP) by setting off from human rights as well as highlighting morally relevant similarities shared amongst human and non-human primates, to then question inherent anthropocentrism. The right to health complements the set of basic negative rights defended by GAP. It does so by developing an interest-based theory of moral rights in line with the work of Alasdair Cochrane, albeit (1) critical of his denial of animal freedom, and (2) more elaborate on the right to health. These rights are brought to bear on the various interfaces between human and non-human great apes, using One Health as a framework for integrating apparently disconnected practices, so as to work towards an interspecies health policy. Show less
