Leiden University Scholarly Publications

Lienden, M.J.C. van der 2021

Investigations on the role of impaired lysosomes of macrophages in disease

Doctoral Thesis

open access

2022-09-18T00:00:00Z; 2022-09-18T00:00:00Z; 2022-09-18T00:00:00Z; 2022-09-18T00:00:00Z

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling. Novel imaging and labelling techniques are applied to provide in... Show moreThe research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling. Novel imaging and labelling techniques are applied to provide in depth characterization of lysosome function in health and disease. An integrative approach was used to study the physiological role of the lysosome, characterizing the function of lysosomal hydrolases and signalling on a cellular level as well as within the context of tissue. Show less

Snel, M. 2011

The effects of a very low calorie diet and exercise in obese type 2 diabetes mellitus patients

Doctoral Thesis

open access

2013-09-02T00:00:00Z; 2011-09-02T00:00:00Z; 2011-09-02T00:00:00Z; 2011-09-02T00:00:00Z; 2013-03-02T00:00:00Z; 2013-03-02T00:00:00Z; 2013-09-02T00:00:00Z; 2013-03-02T00:00:00Z; 2011-09-02T00:00:00Z; 2013-03-02T00:00:00Z; 2013-03-02T00:00:00Z; 2011-09-02T00:00:00Z; 2011-09-02T00:00:00Z; 2011-09-02T00:00:00Z; 2011-09-02T00:00:00Z

This thesis shows the results of a 16-week very low calorie diet on insulin resistance, Quality of Life, low-grade inflammation and ectopic fat depositions