LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.... Show moreLCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability. Three of these issues relate to a) allocation, b) the representation of the time dimension and c) the interpretation of results in LCA. Uncertainties play a fundamental and underlying role for these issues. It is widely-agreed that correctly dealing with these different uncertainty sources is a vital step towards increasing the usefulness and reliability of LCA results. Practical ways to deal with uncertainty are needed. The aim of this thesis is to deepen the understanding of the uncertainty dimension of current LCA. By means of addressing different sources of uncertainty not yet addressed, with new methods, a clearer picture of the implications of different sources of uncertainty in LCA is provided. This thesis departed from broad domains of uncertainty including risk, uncertainty as conventionally described, ignorance and indeterminacies. The selected sources of uncertainty are in the domains of risk and conventional uncertainty i.e. those due to incomplete scientific knowledge and that are to some extent quantifiable. This does not mean that all can be known or quantified as ignorance and indeterminacies exist. Show less
Women from families in which many individuals have developed breast and/or ovarian cancer may request for DNA-testing. A DNA-test result may disclose their own risks to develop cancer (again),... Show moreWomen from families in which many individuals have developed breast and/or ovarian cancer may request for DNA-testing. A DNA-test result may disclose their own risks to develop cancer (again), their relatives__ risks and subsequent options for medical surveillance. This thesis describes several multicenter studies in the Netherlands about the psychological and medical impact of DNA-testing on the lives of these women and their relatives. Despite their accurate understanding of the global meaning of DNA-test result, many participants interpreted the result differently from what the genetic-counselor had actually communicated. Like in a children__s whisper game, their relatives also misinterpreted the information communicated by the first messenger. The messengers__ misinterpretation was not only related to their inaccurate thoughts about heredity and cancer in general, but also to their feelings, and especially to their unfulfilled need for certainty, sense of self and unresolved existential issues. The presence of misinterpretations predicted the extent of the counselees' distress and the medical decisions after DNA-test result disclosure. The study results are described in their historical and theoretical context, followed by practical clinical suggestions for genetic-counselors and psychologists. For instance, we suggest that genetic-counselor try to avoid the communication of ambiguous DNA-test results that do not have medical consequences. Show less
