Rapid socio-economic growth accelerates urbanization in Indonesia, which changes many aspect of human lives, and potentially affect disease prevalence and outcome. This thesis aims to investigate... Show moreRapid socio-economic growth accelerates urbanization in Indonesia, which changes many aspect of human lives, and potentially affect disease prevalence and outcome. This thesis aims to investigate the impacts of urbanization on human health, especially metabolic health and allergic disease, by incorporating many aspects of scientific investigation. Our cluster-randomized-controlled trial showed that, helminth infection, a characteristic feature of rural areas, and anthelmintic treatment, could significantly affect metabolic profiles and hormones. Thus, the ongoing deworming program in Indonesia require in parallel, monitoring of the metabolic health. Additionally, based on our prospective cohort study and analysis on a large scale nationally representative data, although Indonesian rural populations have relatively better metabolic profiles compared to urban, lifelong residence in rural areas does not protect their community members from adverse metabolic changes due to urbanization. Next, we observed that majority of individuals with diabetes in Indonesia were undiagnosed and untreated, especially in rural populations, which warrants extensive action plan from all related stakeholders. Lastly, high-dimensional data analyses on the systemic and nasal mucosal immune profiles revealed a stronger inflammatory immune responses in the nasal mucosal of Indonesian urban young adults with allergic rhinitis compared to their rural counterparts. Show less
Overweight and obesity are abnormal or excessive body fat accumulation that presents a risk to health. The World Health Organisation defines overweight and obesity with the Body Mass Index (BMI)... Show moreOverweight and obesity are abnormal or excessive body fat accumulation that presents a risk to health. The World Health Organisation defines overweight and obesity with the Body Mass Index (BMI) classification, which is a measure of a person’s weight in kilograms (kg) divided by the square of height in meters (m2). Overweight is defined as a BMI of 25 kg/m2 or higher, whereas obesity is defined as a BMI of 30 kg/m2 or higher. It is estimated that one of every three individuals in the global population has overweight. The prevalence of obesity is increased threefold from 1975 to 2016, with a faster-growing pace in low- and middle-income countries than high-income countries. One common complication of obesity is the metabolic syndrome, which is defined as the co-occurrence of at least three out of five cardiometabolic abnormalities (abdominal obesity, hypertension, hyperglycaemia, hypertriglyceridemia, and low HDL-cholesterol). The metabolic syndrome is a strong risk factor for type 2 diabetes and cardiovascular diseases, and is considered a pathway from obesity to the cardiometabolic diseases occurrence. Thus, if metabolic syndrome or its components are identified and treated early, type 2 diabetes and cardiovascular diseases may be prevented. In this multi-ethnic global population, it is well-established that different ethnic populations have different cardiometabolic risks. Studies have shown that Asian populations develop cardiometabolic complications earlier at the same amount of adiposity as the Western populations. Show less
Horst, Sander van der; Lammers, Linde; Maanen, Melle van 2022
Four years of protracted negotiations and bitter warfare passed between the declaration of Indonesian independence on 17 August, 1945, and the official transfer of sovereignty on 27 December, 1949.... Show moreFour years of protracted negotiations and bitter warfare passed between the declaration of Indonesian independence on 17 August, 1945, and the official transfer of sovereignty on 27 December, 1949. Whereas the newly proclaimed Republic of Indonesia rejected the colonial regime and hence any attempt at ‘recolonization’ by the Dutch after the Japanese occupation (1942-1945), the Dutch framed their return to the archipelago as a mission to restore ‘order and peace’. Images of the Indonesian War. Many of these materials, alongside photographs and oral history collections, ended up in the collections of the KITLV and eventually the Leiden University Libraries. This trilingual (English, Dutch and Indonesian) catalogue accompanies a digital exhibition of some fifty unique items. The selection made demonstrates the sharply contrasting perspectives on the legitimacy of the Republic and Dutch colonialism, and also offers first-hand testimonies of a bitter war with a huge imbalance of casualties. Show less
This ethnographic book deals with the emergence of the Wali Pitu (seven saints) tradition and Muslim pilgrimage in Bali, Indonesia. It touches upon the issues of translocal connectivity between... Show moreThis ethnographic book deals with the emergence of the Wali Pitu (seven saints) tradition and Muslim pilgrimage in Bali, Indonesia. It touches upon the issues of translocal connectivity between Java and Bali, Islam-Hindu relationship, relations between Muslim groups, and questions of authority and authenticity of saint worship tradition. It offers a new perspective on Bali, seeing the island as a site of cultural motion straddling in between Islam and Hinduism with complexities of local figurations, and belongings of ‘Muslim Balinese’. The study also urges the intricate relationship between religion and tourism, between devotion and economy, and shows that the Wali Pitu tradition has facilitated the transgression of spatial and cultural boundaries. Show less
This thesis is the first large-scale study of Buddhist and Hindu metal statues (i.e. bronze, gold and silver alloys) from the western islands of the Indonesian Archipelago (Java, Sumatra,... Show moreThis thesis is the first large-scale study of Buddhist and Hindu metal statues (i.e. bronze, gold and silver alloys) from the western islands of the Indonesian Archipelago (Java, Sumatra, Kalimantan, Bawean, Bali, Lombok) since the publication of the catalogue Divine Bronze 31 years ago (Lunsingh Scheurleer & Klokke 1988). To overcome limitations of past studies, I use a network approach inspired by De Casparis’s idea of a “complicated network of relations” linking maritime Southeast Asia and India (1983). Additionally, I apply a multidisciplinary methodology combining art historical methods of stylistic and iconographic analyses with archaeometallurgy (visual examinations, X-ray radiography, neutron tomography, elemental analyses), archaeology for mapping find-spots, as well as religious studies to understand the history of use and ritual functions of sacred images. Examining five case studies drawn from the largest corpus ever considered of Indonesian metal images from museum collections today kept in Indonesia, Europe, and the U.S., my study highlights connections between the Archipelago and other Asian regions—including not only South Asia, but also East Asia—within a large cosmopolitan sphere of interaction and over a long period of time. Show less
Antimicrobial resistance of bacteria is a worldwide and ever-growing problem, directly linked to the use of antimicrobial drugs. Resistant bacteria emerge under the selective pressure of... Show moreAntimicrobial resistance of bacteria is a worldwide and ever-growing problem, directly linked to the use of antimicrobial drugs. Resistant bacteria emerge under the selective pressure of antibiotics. In hospitals, where large-scale usage of antibiotics is common, bacteria frequently become resistant to several antibiotics which causes serious problems for the treatment of patients with infections by these microorganisms. Well-known (multi)-resistant bacteria causing problems in many countries all over the world are methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, penicillin-resistant pneumococci, extended-spectrum betalactamase-producing Klebsiella pneumoniae, carbapenem-resistant Acinetobacter baumannii, and multiresistant Mycobacterium tuberculosis Show less
