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Pak, H.J. 2024

Taking up space: waste and waste labor in developing South Korea

Doctoral Thesis

open access

“Taking Up Space: Waste and Waste Labor in Developing South Korea” examines South Korean development experiences through the remnants of its industrialization and modernization processes, including... Show more“Taking Up Space: Waste and Waste Labor in Developing South Korea” examines South Korean development experiences through the remnants of its industrialization and modernization processes, including material waste, excess labor, or surplus population. I juxtapose the history of informal waste pickers with the transformation of waste management and the reconfiguration of its labor during the period from the 1960s to the early 1990s. By connecting the material, social, and symbolic dimensions of waste, I demonstrate how waste shaped their stigma and social position, degraded the urban environment as much as it deteriorated their living and working conditions, and brought social and environmental forces that further drove their marginalization. The case studies—waste picker camps and Seoul’s Nanjido Landfill—illustrate how concepts such as informality, precarity, and societal marginalization have been historically mediated and grounded in individuals’ lives during the country’s compressed development process.This study demonstrates how the production of marginalized populations and the disregard for their labor practices served to consolidate the developing nation-state and its middle-class citizens. It argues that the informal labor at the urban periphery was instrumental in the development process and should be recognized as legitimate labor rather than mere subsistence activities. Waste pickers not only served as agents of development but also as a precedent for precarious workers in modern Korea. The prevalence of waste pickers in contemporary South Korea indicates a diachronic implication of this dissertation, as their labor remains crucial for urban conditions while simultaneously establishing an urban form of precarity. Show less

Dobbelaar, S. 2023

Helping me, helping you: behavioral and neural development of social competence from childhood to adolescence

Doctoral Thesis

open access

Why do some children easily find their way in social situations and are satisfied with their social lives, while others experience more difficulties? One key component that may explain this is... Show moreWhy do some children easily find their way in social situations and are satisfied with their social lives, while others experience more difficulties? One key component that may explain this is social competence: the ability to fulfill both own and other’s social goals. This thesis focused on individual differences in social competence from childhood to adolescence by examining contextual, developmental and neurobiological influences on aggressive and prosocial responses to social evaluation. Findings showed robust neural processes related to social feedback and subsequent aggression already in middle childhood. Additionally, this thesis revealed that the period between childhood and adolescence is important for the behavioral and neural development of inhibition of aggression following negative, neutral and positive social feedback. Aggression following social feedback decreased towards adolescence, but aggression following positive feedback decreased earlier in childhood than following negative feedback. Moreover, the involvement of the dorsolateral prefrontal cortex, known for its role in executive functioning, decreased over time. Finally, results indicated that the co-occurrence of aggression following rejection and prosocial behavior following observed rejection may possibly protect against externalizing behaviors and promote wellbeing. This thesis highlights the importance of examining the interplay of developmental processes across social contexts to understand mental health outcomes. Show less

Palix, J.; Habersaat, S.; Boonmann, C.; Nauta-Jansen, L.; Schmeck, K.; Fegert, J.M.; ... ; Urben, S. 2023

Examining the relationship between resting heart rate and callous-unemotional traits in juvenile delinquency

Article / Letter to editor

open access

Purpose: Both the resting heart rate (RHR) and the callous-unemotional (CU) traits have been associated with juvenile delinquency, however the effect of their interaction is not yet clear.Methods:... Show morePurpose: Both the resting heart rate (RHR) and the callous-unemotional (CU) traits have been associated with juvenile delinquency, however the effect of their interaction is not yet clear.Methods: Four hundred and twenty-three institutionalized adolescents divided into early adolescents (10-14 years, n = 133), late adolescents (15-17 years, n = 286), and young adults (18-22 years, n = 136) participated in the study. RHR was measured using a wristband, and CU traits and delinquency history were assessed using self-reported questionnaires. Moderation analysis was performed to understand how the combination between RHR and CU is associated to offending.Results: CU traits were associated with offending at all ages. The interactions between RHR and CU traits were significantly related to the likelihood of offending in the early and the late adolescent. The highest likelihood of offending is related to high CU traits combined with low RHR in early adolescents and with high RHR in late adolescents.Conclusions: These findings provide further insight in the relationship between psychopathic traits and bio-physiological maturation in explaining juvenile delinquency. Show less

Kusters, M.C.J.; Rijst, R.M. van der; Vetten, A.J. de; Admiraal, W.F. 2023

University lecturers as change agents: how do they perceive their professional agency?

Article / Letter to editor

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The delicate balance between teaching and research in university makes professional agency an imperative topic to be studied in teacher development research. The importance of teacher agency for p... Show moreThe delicate balance between teaching and research in university makes professional agency an imperative topic to be studied in teacher development research. The importance of teacher agency for professional development and sustainable educational change is increasingly recognized. This interview study highlights lecturers’ experiences regarding ways to influence and develop their teaching practices. Lecturers stated that they would like to do more educational development. Findings also indicate that the concept of professional agency should be adapted to the particular context of university teaching. Our study therefore provides a more specific interpretation of professional agency applied to teaching. Show less

Stathopoulos, A. 2023

Rising for whom?

Article / Letter to editor

open access

The increase of African per capita growth figures led international organisations, the media and pundits to proclaim that the rise of Africa is inevitable, as the result of novel policies and an... Show moreThe increase of African per capita growth figures led international organisations, the media and pundits to proclaim that the rise of Africa is inevitable, as the result of novel policies and an improved environment in the continent. Ian Taylor, in his article ‘Is Africa rising?’, is questioning the arguments on which this narrative is based. The present piece seeks to discuss the main contributions of Taylor’s article and show how it has influenced debates on the topic. Show less

Czukiewska, S.M.; Lopes, S.M.C.D. 2022

Fetal germ cell development in humans, a link with infertility

Article / Letter to editor

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Gametes are cells that have the unique ability to give rise to new individuals as well as transmit (epi)genetic information across generations. Generation of functionally competent gametes, oocytes... Show moreGametes are cells that have the unique ability to give rise to new individuals as well as transmit (epi)genetic information across generations. Generation of functionally competent gametes, oocytes and sperm cells, depends to some extent on several fundamental processes that occur during fetal development. Direct studies on human fetal germ cells remain hindered by ethical considerations and inaccessibility to human fetal material. Therefore, the majority of our current knowledge of germ cell development still comes from an invaluable body of research performed using different mammalian species. During the last decade, our understanding of human fetal germ cells has increased due to the successful use of human pluripotent stem cells to model aspects of human early gametogenesis and advancements on single-cell omics. Together, this has contributed to determine the cell types and associated molecular signatures in the developing human gonads. In this review, we will put in perspective the knowledge obtained from several mammalian models (mouse, monkey, pig). Moreover, we will discuss the main events during human fetal (female) early gametogenesis and how the dysregulation of this highly complex and lengthy process can link to infertility later in life. Show less

Maurice-Stam, H.; Erp, L.M.E. van; Maas, A.; Oers, H.A. van; Kremer, L.C.M.; Dulmen-den Broeder, E. van; ... ; Dutch LATER Study Grp 2022

Psychosocial developmental milestones of young adult survivors of childhood cancer

Article / Letter to editor

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Purpose The study aimed to compare the psychosocial development of young adult survivors of childhood cancer (YACCS) with a norm group of young adults from the general population. Methods From 2017... Show morePurpose The study aimed to compare the psychosocial development of young adult survivors of childhood cancer (YACCS) with a norm group of young adults from the general population. Methods From 2017 to 2020, 558 YACCS (18-30 years, 51% female, 10.9% CNS cancer) who participated in the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort (diagnosed 1963-2001) part 2 completed the Course of Life Questionnaire (CoLQ), assessing the achievement of milestones. Items were grouped into the scales autonomy, psychosexual, and social development. Differences between YACCS and norm group were examined with ANOVA and Cohen's d (CoLQ scales) and with logistic regression analysis and odds ratio (OR) (CoLQ items), for the total group and YACCS of CNS cancer. Results The total group of YACCS did not report a less favorable psychosocial development than the norm group. YACCS of CNS cancer scored lower than the norm group (p < 0.001) on the scales autonomy (d = - 0.36) and psychosexual (d = - 0.46). Additionally, on half of the items of autonomy (0.25 <= OR <= 0.34), psychosexual (0.30 <= OR <= 0.48), and social (0.23 <= OR <= 0.47) development, YACCS of CNS cancer were less likely (p < 0.01) than the norm group to have achieved the milestones. Conclusion Overall, psychosocial development of YACCS was as favorable as the norm, but YACCS of CNS cancer were at risk of an unfavorable psychosocial development in all domains. Monitoring psychosocial development should be included in the standards of psychosocial care, especially for CNS cancer patients and survivors, to be able to trace delay. Personalized interventions should be offered to improve the psychosocial development in an early stage. Show less

Dellar, M.E.; Boerlijst, S.P.; Holmes, D.S.T. 2022

Improving estimations of life history parameters of small animals in mesocosm experiments: a case study on mosquitoes

Article / Letter to editor

open access

Mesocosm experiments enable researchers to study animal dynamics, but determining accurate estimates of survival and development rates of different life stages can be difficult, especially as the...

Mesocosm experiments enable researchers to study animal dynamics, but determining accurate estimates of survival and development rates of different life stages can be difficult, especially as the subjects may be hard to sample and mortality rates can be high. We propose a new methodology for estimating such parameters.
We used an experimental set-up with 48 aquatic mesocosms, each with 20 first instar mosquito larvae and under 1 of 12 treatments with varying temperatures and nutrient concentrations. We took daily subsamples of the aquatic life stages as well as counting the emerging adults. We developed a method to estimate the survival and development probabilities at each life stage, based on optimising a matrix population model. We used two different approaches, one assuming the difference between predictions and observations was normally distributed, and the other using a combination of a normal and a multinomial distribution. For each approach, the resulting optimisation problem had around 100 parameters, making conventional gradient descent ineffective with our limited number of data points. We solved this by computing the formal derivatives of our matrix model.
Both approaches proved effective in predicting mosquito populations over time, also when compared against a separate validation dataset, and the two approaches produced similar results. They also both predicted similar trends in the survival and development probabilities for each life stage, although there were some differences in the actual values. The approach which only used the normal distribution was considerably more computationally efficient than the mixed distribution approach.
This is an effective approach for determining the survival and development rates of small animals in mesocosm experiments. We have not found any other reliable methodology for estimating these parameters, especially not from incomplete data or when there are many different experimental treatments. This methodology enables researchers to gain a much more detailed understanding of the life cycles of small animals, potentially leading to advances in a wide range of areas, for example in mosquito-borne disease risk or in considering the effects of biodiversity loss or climate change on different species.

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Balazadeh, S. 2022

A ‘hot’ cocktail: the multiple layers of thermomemory in plants

Article / Letter to editor

open access

Heat stress (HS) caused by above-optimal temperatures adversely affects plants’ growth and development and diminishes crop yields. In natural and agricultural environments, these stresses are often... Show moreHeat stress (HS) caused by above-optimal temperatures adversely affects plants’ growth and development and diminishes crop yields. In natural and agricultural environments, these stresses are often transient but recurrent and may progressively increase in severity over time. In addition to the inherent ability to cope with a single HS event, plants have evolved mechanisms that enhance their capacity to survive and reproduce under such conditions. This involves the establishment of a molecular ‘thermomemory’ after moderate HS that allows them to withstand a later — and possibly more extreme — HS event. Here, I summarize the current understanding of the molecular and biochemical mechanisms underlying thermomemory across multiple cellular levels and discuss aspects that require further attention. Show less

Abbink, G.J. 2022

Ethiopia

Part of book or chapter of book

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Abbink, G.J. 2022

Somalia

Part of book or chapter of book

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Walraven, K. van 2022

Niger

Part of book or chapter of book

metadata only

Liu, Q. 2021

Bearing with noise: the effects of highway noise on behaviour and development in zebra finches

Doctoral Thesis

open access

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups. Especially for birds, a substantial number of observational studies have now shown negative associations between... Show moreAnthropogenic noise negatively affects wildlife in a wide range of taxonomic groups. Especially for birds, a substantial number of observational studies have now shown negative associations between noise pollution and abundance and diversity along roadsides. Researchers investigating birds’ behavioural responses to high level noise to date have mostly focused on the immediate adjustment of vocal signalling behaviour. However, there is more than one mechanism by which birds might cope with increasing noise levels. They may show immediate behavioural reactions, such as spatial avoidance and/or vocal adjustment, but also more ontogenetic adjustments with long-term consequences like changes in sensory and personality traits. To test these potential effects of traffic noise on birds, I conducted a series of experiments using zebra finches. I have demonstrated that traffic noise per se can contribute to spatial avoidance in birds and cause variation in parental behaviour, and that there can be changes in noise avoidance behaviour in the course of a lifetime. These results provide new insights into the potential impacts of noise on birds. Show less

Suryani, A.J. 2021

From respected hermits to ordinary citizens: The conversion of the Baduy, ethnicity, and politics of religion in Indonesia (1977 - 2019)

Doctoral Thesis

open access

This dissertation is about the Baduy, an adat community in Banten Province, Indonesia. It argues that the conversion of the Baduy was influenced by their self-concept, which requires them to detach... Show moreThis dissertation is about the Baduy, an adat community in Banten Province, Indonesia. It argues that the conversion of the Baduy was influenced by their self-concept, which requires them to detach from modernity and development, the limited size of their land, and the increase of the population. This process of conversion was supported by the politics of religion, which differentiates local beliefs (kepercayaan) from state-recognised religions (agama) where adhering to a local belief was considered irreligious (tidak/ belum beragama) and backward. To make the adherents of local beliefs religious, the government allows followers of major religions to invite the adherents of local beliefs into their faith. Furthermore, to develop the adherents of local beliefs, the government created development policies, in particular a resettlement programme. The programme aimed at Baduy society began in 1977 and lasted until 1999. Besides developing the adat communities, this programme was also aimed at changing their beliefs so that they aligned themselves with “monotheistic views”. The fact that Muslim and Christian missionaries were targeting the same group of people caused tension, contestation, and even violence. Confronted with this situation, the adherents of local beliefs fought back and resisted the policies in various ways. Show less

Dishoeck, E.F. van 2021

The IAU and education: introduction

Article / Letter to editor

open access

Beier, R.; Strava, C. 2020

Losing or gaining home? Experiences of resettlement from Casablanca’s slums

Part of book or chapter of book

open access

Stoelinga, F. 2020

Albert Winsemius: De Nederlander achter de BV Singapore

Doctoral Thesis

open access

Between 1960 and 1983 the Dutch economist Dr. Albert Winsemius (1910-1996) was the most influential economic adviser to the government of Singapore and one of the leading architects of Singapore’s... Show moreBetween 1960 and 1983 the Dutch economist Dr. Albert Winsemius (1910-1996) was the most influential economic adviser to the government of Singapore and one of the leading architects of Singapore’s highly successful development model. Winsemius' beliefs and recommendations chimed with the views of Singapore’s first-generation postcolonial political leaders and quickly grew in popular appeal once they started yielding impressive economic results. Winsemius’ uncompromising hostility to communism, and at the same time his sympathy toward moderate trade unionism, were of particular importance here.This research identifies strategies and policies that contributed to Singapore's development, and that can be traced to Albert Winsemius as a historical principal. It concludes that in essence, many of these successful strategies and policies were based on Winsemius’ experiences in his earlier life and career: the economic reconstruction in the Netherlands in the years after World War Two, in which he played a key role, his empathy toward the United States and the American way of life, his contacts with other right-wing governments, and his involvement during the Cold War in the production of arms. Show less

Peterson, J.C.; Wisse, L.J.; Wirokromo, V.; Herwaarden, T. van; Smits, A.M.; Groot, A.C.G.; ... ; DeRuiter, M.C. 2020

Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy

Article / Letter to editor

open access

Patients with a congenital bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, have an increased risk of developing thoracic aneurysms and aortic dissection. The... Show morePatients with a congenital bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, have an increased risk of developing thoracic aneurysms and aortic dissection. The mechanisms underlying BAV-associated aortopathy are poorly understood. This study examined BAV-associated aortopathy in Nos3(-/-) mice, a model with congenital BAV formation. A combination of histological examination and in vivo ultrasound imaging was used to investigate aortic dilation and dissections in Nos3(-/-) mice. Moreover, cell lineage analysis and single-cell RNA sequencing were used to observe the molecular anomalies within vascular smooth muscle cells (VSMCs) of Nos3(-/-) mice. Spontaneous aortic dissections were found in ascending aortas located at the sinotubular junction in similar to 13% of Nos3(-/-) mice. Moreover, Nos3(-/-) mice were prone to developing aortic dilations in the proximal and distal ascending aorta during early adulthood. Lower volumes of elastic fibres were found within vessel walls of the ascending aortas of Nos3(-/-) mice, as well as incomplete coverage of the aortic inner media by neural crest cell (NCC)-derived VSMCs. VSMCs of Nos3(-/-) mice showed downregulation of 15 genes, of which seven were associated with aortic aneurysms and dissections in the human population. Elastin mRNA was most markedly downregulated, followed by fibulin-5 expression, both primary components of elastic fibres. This study demonstrates that, in addition to congenital BAV formation, disrupted endothelial-mediated nitric oxide (NO) signalling in Nos3(-/-) mice also causes aortic dilation and dissection, as a consequence of inhibited elastic fibre formation in VSMCs within the ascending aorta. Show less

Balak, J.R.A.; Juksar, J.; Carlotti, F.; Nigro, A. lo; Koning, E.J.P. de 2019

Organoids from the Human Fetal and Adult Pancreas

Article / Letter to editor

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Purpose of Review Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue... Show morePurpose of Review Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue-derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.Recent Findings Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses.Summary Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening. Show less

Li, N. 2019

Development of the human fetal immune system: novel insights from high-dimensional single-cell technologies

Doctoral Thesis

open access

Several studies have highlighted the uniqueness of the human immune system in early life. Due to the scarceness of human fetal tissues and technical limitations, a system-wide and detailed... Show moreSeveral studies have highlighted the uniqueness of the human immune system in early life. Due to the scarceness of human fetal tissues and technical limitations, a system-wide and detailed phenotypical characterization of the composition and development of the human fetal immune system was lacking. Here, I delineate the composition and development of the human fetal immune system using an array of advanced high-throughput technologies. First, mass cytometry analysis of the innate lymphoid cells revealed a previously unrecognized subset named int-ILC in the fetal intestine, which can give rise to NK cells and ILC3s. Moreover, by combining the acquired datasets from (imaging-) mass cytometry, single-cell RNA-sequencing and TCR sequencing with advanced computational analysis tools and functional analysis this revealed that memory-like CD4+ T cells were already generated in the developing human fetal intestine, indicative of in utero exposure to foreign antigens. Additionally, (imaging-) mass cytometry analysis of the immune cells in the fetal intestine, spleen and liver revealed an early-life immune compartmentalization in these different fetal tissues. Overall, our results deepens the understanding of prenatal immunity and may ultimately be useful for the development of “early” intervention strategies to prevent the development of immune mediated diseases later in life. Show less

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