The use of data derived from genomics and transcriptomic to further develop our understanding of Polycystic Kidney Diseases and identify novel drugs for its treatment.
In general, biological and chemical causes for harmful effects were studied through bioinformatics and cheminformatics efforts. A database of human genetic variants in G protein-coupled receptors... Show moreIn general, biological and chemical causes for harmful effects were studied through bioinformatics and cheminformatics efforts. A database of human genetic variants in G protein-coupled receptors was constructed, and differences between neutral and harmful variants were studied. A database of compounds with their mutagenicity data was constructed, and substructures were extracted that distinguish between Ames positive and Ames negative compounds. 6. Keywords (At most 10, in English), preferably from the thesaurus in use within your discipline. Do not use very general terms. cheminformatics, chemoinformatics, bioinformatics, databases, data mining, drug discovery, SNPs, polymorphisms, substructures. Show less
