Leiden University Scholarly Publications

Rappe, J.C.F.; Wilde, A. de; H. di; Muller, C.; Stalder, H.; V'kovski, P.; ... ; Thiel, V. 2018

Antiviral activity of K22 against members of the order Nidovirales

Article / Letter to editor

open access

Kuri, T.; Eriksson, K.K.; Putics, A.; Zuest, R.; Snijder, E.J.; Davidson, A.D.; ... ; Weber, F. 2011

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

Article / Letter to editor

metadata only

Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1 ''-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The... Show moreSeveral plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1 ''-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host. Show less