Leiden University Scholarly Publications

Waaijer, M.E.C.; Gunn, D.A.; Heemst, D. van; Slagboom, P.E.; Sedivy, J.M.; Dirks, R.W.; ... ; Maier, A.B. 2018

Do senescence markers correlate in vitro and in situ within individual human donors?

Article / Letter to editor

open access

Waaijer, M.E.C.; Parish, W.E.; Strongitharm, B.H.; Heemst, D. van; Slagboom, P.E.; Craen, A.J.M. de; ... ; Maier, A.B. 2012

The number of p16INK4a positive cells in human skin reflects biological age

Article / Letter to editor

metadata only

Waaijer, M.E.C.; Parish, W.E.; Strongitharm, B.H.; Heemst, D. van; Slagboom, P.E.; Craen, A.J.M. de; ... ; Maier, A.B. 2012

The number of p16INK4a positive cells in human skin reflects biological age

Article / Letter to editor

metadata only

Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than... Show moreCellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence. We observed that a younger biological age associates with lower levels of p16INK4a positive cells in human skin. Show less