We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We... Show moreWe conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P < 5 x 10(-8)), while five of the 21 lead SNPs reach suggestive significance (P < 1 x 10(-5)) for at least one other macronutrient. While the phenotypes are genetically correlated, each phenotype carries a partially unique genetic architecture. Relative protein intake exhibits the strongest relationships with poor health, including positive genetic associations with obesity, type 2 diabetes, and heart disease (r(g) approximate to 0.15-0.5). In contrast, relative carbohydrate and sugar intake have negative genetic correlations with waist circumference, waist-hip ratio, and neighborhood deprivation (|r(g)| approximate to 0.1-0.3) and positive genetic correlations with physical activity (r(g) approximate to 0.1 and 0.2). Relative fat intake has no consistent pattern of genetic correlations with poor health but has a negative genetic correlation with educational attainment (r(g) approximate to-0.1). Although our analyses do not allow us to draw causal conclusions, we find no evidence of negative health consequences associated with relative carbohydrate, sugar, or fat intake. However, our results are consistent with the hypothesis that relative protein intake plays a role in the etiology of metabolic dysfunction. Show less
Motivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity... Show moreMotivation: The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene.Main types of variables included: The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record.Spatial location and grain: BioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km(2) (158 cm(2)) to 100 km(2) (1,000,000,000,000 cm(2)).Time period and grainBio: TIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year.Major taxa and level of measurement: BioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates. Show less
Cichutek, K.; Epstein, J.; Griffiths, E.; Hindawi, S.; Jivapaisarnpong, T.; Klein, H.; ... ; WHO Expert Comm Biological 2017
In literature ghosts have a long history. They manifest themselves in a variety of forms. They are intriguing because of their undecidable nature—their association with death and afterlife, which... Show moreIn literature ghosts have a long history. They manifest themselves in a variety of forms. They are intriguing because of their undecidable nature—their association with death and afterlife, which are irredeemable and inexplicable to the living. Especially in postcolonial literature we encounter the presence of ghosts. Ghostly figures often serve as metaphors of return—the return of repressed history, which continues to haunt the present. Sometimes they mark a present absence of marginalized groups of people. Noting the ineluctable encounters between ghosts, memories, and subjectivities in postcolonial literature, this dissertation tries to reach a deeper and broader understanding of the narrative potential of the ghostly in spatial, cultural and ethical dimensions. By perceiving ghosts as metaphorical concepts, I incorporate a variety of notions of ghosts into my exploration of ‘spectral space,’ ‘ghost language,’ and ‘mediums.’ I also investigate how these ghost-related concepts function to illuminate a new mode of thinking about the realms of knowledge and ethics. I argue that ghosts are ethical subjects rather than objects of social constructions. They provide us a productive way of establishing a new ethics of ghosts, which is reconsidered as the ethics of how to live with and survive as ghosts. Show less
Mease, P.; Heijde, D. van der; Ritchlin, C.; Cuchacovich, R.; Shuler, C.; Lin, C.Y.; ... ; Gladman, D. 2016
