In conclusion, this thesis proposes a new approach for reconstruction of coronary artery and the implanted BRS by fusion of OCT and X-ray angiography to analyze intracoronary ESS in vivo. The... Show moreIn conclusion, this thesis proposes a new approach for reconstruction of coronary artery and the implanted BRS by fusion of OCT and X-ray angiography to analyze intracoronary ESS in vivo. The studies conducted in this thesis demonstrate the feasibility of the proposed approach to analyze the detailed local coronary hemodynamics in patients, including the SS patterns after BRS implantation in coronary bifurcations. We observed that in vivo assessment of ESS was closely related to: (1) reconstruction of the side branches; (2) reconstruction of the BRS; (3) patient-specific flow; (4) post-processing portion size in which ESS was calculated. Based on these findings, we propose the following standard analysis procedures for assessment of intracoronary ESS in vivo: (1) reconstruct both the main vessel and its side branches to create a more accurate geometric model. (2) reconstruct BRS in naturally-bent shape and include it in the CFD analysis for assessment of ESS after BRS implantation; (3) use patient-specific coronary flow in the CFD analysis to have more accurate boundary condition; (4) set the proportion size according to the interrogated region of interest for quantification of the ESS in portions. Show less
In contemporary clinical practice, multimodality invasive assessment of coronary lesions offers an invaluable insight on clinical decision-making and PCI-guidance. Intracoronary imaging and... Show moreIn contemporary clinical practice, multimodality invasive assessment of coronary lesions offers an invaluable insight on clinical decision-making and PCI-guidance. Intracoronary imaging and functional assessment are two different diagnostic entities that offer complementary, rather than competitive, information. The role of this integrative understanding during a heart catheterization procedure is of outmost importance to achieve optimal procedural results, particularly regarding complicated coronary anatomies. Furthermore, this holistic approach can potentially lead to outcome improvement in patients with CAD treated percutaneously. Show less
