Producing the local: Javanese performance on Indonesian television explores how television represents Javaneseness, as a factor designed to catch and keep the attention of its putative... Show moreProducing the local: Javanese performance on Indonesian television explores how television represents Javaneseness, as a factor designed to catch and keep the attention of its putative audiences. Central is the question of how people make use of national, regional, local, public and private television in Indonesia – each in their own way and with their own goals – to represent the local and, in particular, how they construct images of Javaneseness through the production and dissemination of performance. Performance in Javanese has been used by the Indonesian television industry to achieve various purposes: to entertain and inform its audiences, to represent the local/the regional, to preserve and nurture the traditional and to build national culture, for persuasive (commercial or propaganda) aims, as a counter-voice of diversification towards global or Jakartan influences, and to express multiculturalism. These issues have been put into the framework of discursive practices about local, national and global cultures in the electronic audiovisual media in Indonesia. Three main themes structure the study: representing tradition, localizing persuasion and mediating the local. Above all, this dissertation is a plea for a more thorough study of the role of proximity in the production, dissemination and reception of local television programmes. Show less
The main objective of this thesis is to improve understanding of the role of helminth infections in the development of insulin resistance (IR), hence Type 2 Diabetes (T2D), in the light of... Show moreThe main objective of this thesis is to improve understanding of the role of helminth infections in the development of insulin resistance (IR), hence Type 2 Diabetes (T2D), in the light of increasing urbanization in Indonesia. Our large-scale cluster-randomized controlled trial was performed in a rural area of Indonesia, which is endemic for soil-transmitted helminth (STH), and has been previously reported to have a low prevalence of IR and T2D. In STH-infected subjects, as assessed by microscopy, 12-month anthelmintic treatment increased IR, which was mediated by an increase in BMI and leptin to adiponectin ratio, as well as reduction in eosinophil count. Next, we also aimed to assess the different metabolic profile between populations living in rural and urban area, and to study the relative protective effect of rural environment to high-fat diet (HFD). In comparison to those living in rural area, individuals living in urban area had higher whole body IR, which was mainly mediated by the higher adiposity and leptin level, which were progressively increased with increased duration of time spent in urban area. Different environmental factors (including past or current exposure to STH) did not seem to affect the metabolic response to HFD intervention, independent from adiposity. Show less
Parasitic helminths are important organisms to study because their infections have both adverse and beneficial effects on the human host. Helminth infections are considered a burden, as these... Show moreParasitic helminths are important organisms to study because their infections have both adverse and beneficial effects on the human host. Helminth infections are considered a burden, as these infections cause significant morbidity in a large proportion worldwide. However, helminth infections, by means of their ability to modify host immune responses can also provide protection against inflammatory diseases (inflammatory bowel disease, diabetes, and asthma). It is important to better understand the underlying mechanisms of these Yin (positive) and Yang (negative) consequences of helminth infections. The general objective of this thesis is to track helminths at different levels. On the one hand to improve the detection of helminth infections, essential for the studying helminths and the interaction with their human host. Moreover, a more sensitive diagnostics is instrumental for monitoring the distribution of helminth infections and to evaluate the helminth infections elimination program. On the other hand, to understand the mechanistic insights of the interplay between helminths and the host immune system results in priming of Th2 and regulatory T cell responses. This could contribute to the identification of targeted pathways to manipulate immune responses, as part of developing therapeutics to treat inflammatory disorders characterized by deregulated Th2 and/or Treg responses. Show less
