Despite the value of technology integration for educational equity and quality being emphasized by numerous studies, many gaps exist about how technology integration can be approached in policy... Show moreDespite the value of technology integration for educational equity and quality being emphasized by numerous studies, many gaps exist about how technology integration can be approached in policy plans, implemented in pedagogical practices, and embraced by teachers, students, and parents. In the current dissertation, the focus is on teachers’ pedagogical practices with technology in primary and secondary education, contributing to a more detailed understanding of what happens to integrate technology into the teaching and learning processes. Given this goal, we examined the different teaching and technology practices considering the concerted efforts of various stakeholders at different levels and contexts. Five studies were performed on: (1) an overview of the link between local information and communications technology (ICT) policy plans and the ICT practices of rural schools; (2) rural teachers’ use of digital educational resources aimed at promoting digital equity and education for all; (3) rural teachers’ sharing of digital educational resources aimed at promoting teacher professional learning opportunities and development; (4) (a meta-analysis on) the effectiveness of various mobile technology usage on learning outcomes in primary and secondary education; (5) the relationships among teacher beliefs, classroom process quality, and student engagement in smart classroom learning environments in secondary education. Show less
This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China. As discussed in chapter 1, being responsible for about 84% of the Chinese CO2 emissions in 2015, the... Show moreThis thesis studied in depth the energy use and CO2 emissions of the industrial sector in China. As discussed in chapter 1, being responsible for about 84% of the Chinese CO2 emissions in 2015, the industrial sector plays a vital role in achieving the emission goals for China. The regional and sectoral heterogeneities have been considered since the industrial sector is distributed in different regions and consists of different sub-sectors. Chapter 2 studied the regional heterogeneity in industrial carbon intensity and its drivers in specific years of 1999. 2005, 2010 and 2015. Chapter 3 investigated the driving forces of industrial aggregate energy intensity (IAEI) and the contribution of each industrial sub-sector to the changes in IAEI. Chapter 4 studied to what extent performance convergence of energy-intensive industries across provinces can contribute to CO2 emission reductions and China’s emission goals. Chapter 5 provided a critical literature review on the historical drivers of industrial CO2 emissions and the projected ranges for future emissions against the backdrop of policy goals, both for the industrial sector as a whole, and for the major industrial sub-sectors (electricity generation, cement production, steel production, chemicals, petroleum and non-ferrous metals). Show less
Spiking neural P systems are a class of distributed and parallel computing models inspired by the neurophysiological behavior of neurons sending electrical impulses (spikes) along axons to other... Show moreSpiking neural P systems are a class of distributed and parallel computing models inspired by the neurophysiological behavior of neurons sending electrical impulses (spikes) along axons to other neurons. In this thesis, we consider that the spiking neural P systems are universal even if the systems work in limited asynchronous mode. And we also investigated different variants of spiking neural P systems with other additional features, such as the axon functioning, the growth of dendritic trees in neurons, the positive or negative weights on synapses, and the astrocytes having excitatory and inhibitory influence on synapses. Show less
This thesis consists of two parts, focusing on CD4+CD25+ regulatory T cells (Tregs) (Part I) and IgG glycosylations (Part II), respectively. Part I (Chapter 2-5) is mainly dedicated to a better... Show moreThis thesis consists of two parts, focusing on CD4+CD25+ regulatory T cells (Tregs) (Part I) and IgG glycosylations (Part II), respectively. Part I (Chapter 2-5) is mainly dedicated to a better identification/characterization and generation of functional human Tregs in vitro. In Chapter 2, we investigated the dynamics of endogenous FOXP3 expression and its relation to the suppressive function in activated human CD4+ T cells. In Chapter 3, we discovered an inverse correlation between membrane-bound TNF-alpha expression and cell suppressive abilities within human CD4+CD25++ T-cell compartment. In Chapter 4 & 5, we developed efficient approaches to consistently convert effector T cells into Tregs both in mice and humans. The underlying mechanisms responsible for the inconsistency in Treg conversion were unraveled as well. Part II (Chapter 6-7) aims to analyze the glycosylation pattern of antigen-specific antibodies and to obtain more insights on how glycosylation is regulated during an active immune response. Chapter 6 describes a method for the microscale purification and Fc-glycosylation analysis of auto-antibodies in patients with rheumatoid arthritis. In Chapter 7, we identified, by using an in vitro culture system, some factors that can influence the gylcan pattern of secreted IgG1 during the activation and differentiation of B cells. Show less
