To an increasingly greater degree, incidents and crises are dominating daily life. In this context, mayors are seen as the guardian of local society. As commander-in-chief of the municipal... Show more To an increasingly greater degree, incidents and crises are dominating daily life. In this context, mayors are seen as the guardian of local society. As commander-in-chief of the municipal crisis authority, with increasing frequency they are confronted with the extremely difficult task to manage crises effectively. Mayors are expected by many to display more leadership during crises than during normal day-to-day practice. This thesis describes research into antecedents, moderators, outcomes and contingencies of effective leadership behaviour during times of crisis, paying particular attention to the performance of mayors, as heads of local authority, in the Netherlands in their role of crisis manager. What determines the success of the leadership of mayors during crises; their personality, the leadership context (its possible variations), or both? It was demonstrated that agreeableness differs in relevance for autocratic and participative leadership behaviour of the mayor. The extent to which the leadership behaviour in question is effective, was shown to also be determined by the situation. Where an autocratic line of action is sometimes inevitable—when there is high time pressure, the effectiveness of participative leadership behaviour can be connected to different team processes, especially when the crisis situation is characterised by a high level of ambiguity. Show less
The research in this thesis was aimed at identifying and characterizing novel migraine gene mutations and pathways. Several FHM and non-FHM genes were investigated in patients with monogenic... Show moreThe research in this thesis was aimed at identifying and characterizing novel migraine gene mutations and pathways. Several FHM and non-FHM genes were investigated in patients with monogenic familial hemiplegic migraine or other monogenic disorders in which migraine can be prevalent. Functional consequences of these mutations and the clinical phenotypes associated with them were investigated. Common migraine with a complex genetic background was studied using a genome-wide association analysis in an isolated population and with a meta-analysis study. Furthermore, FHM1 mice were used to study expression profiles in brain tissues that are relevant for the induction of cortical spreading depression ___ underlying the migraine aura - (i.e., the occipital cortex) and cerebellar ataxia (i.e., the cerebellum). These studies will further our insight in the molecular pathophysiology of migraine. Show less
