In this thesis, we identify and/or analyse a couple of regulators of the TGF-β and Wnt signal transduction pathways that play important roles in breast cancer. Our aim was to understand how these... Show moreIn this thesis, we identify and/or analyse a couple of regulators of the TGF-β and Wnt signal transduction pathways that play important roles in breast cancer. Our aim was to understand how these regulators affect the different steps of these pathways, including receptor activation, post-translational modification of other transducing molecules, target gene transcription, as well as crosstalk with other cell signaling pathways. Insight in these mechanisms is expected to help to design strategies for therapeutic intervention in TGF-β and Wnt mediated breast cancer progression. Show less