This dissertation focused on the neural and behavioral mechanisms underlying adolescent learning and mental health in the context of peers and friends. The neuroimaging findings revealed that... Show moreThis dissertation focused on the neural and behavioral mechanisms underlying adolescent learning and mental health in the context of peers and friends. The neuroimaging findings revealed that reward processing for self and peers rely on common reward-related brain regions, whereas a social brain region (TPJ) showed social specificity to observed outcomes for unfamiliar peers compared to friends. Moreover, typically developing adolescents and adolescents with ADHD show neural sensitivity in reward and salience brain regions towards rewards for themselves, friends and peers compared to losses. There were no group differences in neural processing of (vicarious) outcomes between adolescents with and without ADHD, yet a symptom-level approach showed more neural sensitivity for own compared to friends’ losses in individuals with more inattention symptoms. The behavioral findings indicated that adolescents’ learning performance benefitted from observing the choices and outcomes of peers irrespective of the relationship with this peer. The results did not show effects of friendship (quality) and social status on observational and academic learning, but there was a protective effect of friendship quality on internalizing problems. Taken together, these findings highlight adolescence as a period of observational learning opportunities from different types of peers. Adolescence can also serve as a window of opportunity to improve mental health by fostering high-quality friendships. Show less
Two types of financial incentives can help improve healthy lifestyles: carrots (a reward where one can gain something) and sticks (a deposit contract where one can lose something). In a deposit... Show moreTwo types of financial incentives can help improve healthy lifestyles: carrots (a reward where one can gain something) and sticks (a deposit contract where one can lose something). In a deposit contract, participants deposit own money and can lose or earn it back depending on lifestyle changes. We studied the potential of deposit contracts to stimulate a healthy lifestyle.A smartphone app was developed together with the Swiss university ETH Zurich to conduct experimental research into the effects of deposit contracts. In addition, we collaborated with the American company WayBetter to observe the effects of commercially available deposit contracts. Finally, the opinion of people with cardiovascular disease and healthcare professionals regarding financial incentives and deposit contracts for lifestyle change was investigated.The results show that deposit contracts can have strong effects on exercise behavior (daily step counts) in the short term. The results also show that voluntary participation in deposit contracts is limited, but can be increased by doubling the amount deposited and by allowing participants to determine the amount themselves. Finally, healthcare providers think it is a good idea to use financial incentives, but people with cardiovascular disease themselves are skeptical about the use of deposit contracts. Show less
This thesis generated insights into the neural and affective signatures of connectedness between parents and adolescents and between people in general, which is operationalized by responses to eye... Show moreThis thesis generated insights into the neural and affective signatures of connectedness between parents and adolescents and between people in general, which is operationalized by responses to eye contact and empathy. Overall, our findings show that during adolescence, parents are still highly attuned to their child at the neural and affective level. In addition, adolescents report to feel more connected with their parents than with unknown others, although this was not directly reflected in stronger neural responses. Another interesting finding is that making eye contact for a prolonged period generally enhanced the socio-emotional connection between people, both between parents and adolescents and with unknown others. For individuals with a history of CEM and depressed adolescents eye contact is less socially rewarding, however, and does not seem to foster a stronger connectedness with others. Studying the psychobiological underpinnings of affiliative bonding, including the parent-adolescent bond, brings us a step closer to unraveling how such bonds are established and maintained during adolescence. And even more important: Once we know how these bonds are established, we might be better able to modify and repair these bonds in situations in which they for some reason got disrupted. Show less
Despite decades of research from psychology, anthropology, biology and economics, how social preferences arise and vary across contexts remains an open question. In three empirical chapters, this... Show moreDespite decades of research from psychology, anthropology, biology and economics, how social preferences arise and vary across contexts remains an open question. In three empirical chapters, this dissertation addresses this gap using a variety of economic games and neuroimaging techniques that allow for a tractable modeling of cooperation and competition. Overall, findings suggest that while social preferences are linked to neural structure, they can also adapt to environmental factors as well as beliefs about interaction partners. This doctoral thesis shows that interacting with ingroup or outgroup members, taking decisions publicly or privately, and knowing whether we may interact with others again affect our cooperative behavior. These results highlight the importance of understanding how prosociality may be altered and lay the foundations for policy makers to further those social environments that encourage prosocial behavior. Show less
By monitoring ongoing actions and performance outcomes, we are able to detect errors or mismatches between our intentions or predictions. Disturbances in such performance-monitoring processes may... Show moreBy monitoring ongoing actions and performance outcomes, we are able to detect errors or mismatches between our intentions or predictions. Disturbances in such performance-monitoring processes may importantly contribute to impaired adaptive behavior in clinical disorders, such as excessively impulsive behavior in externalizing disorders or excessively rigid or careful behavior in anxiety- and obsessive-compulsive disorders. In daily life, performance monitoring often takes place in a social context, where our actions have consequences not only for ourselves, but also for others. The investigation of (alterations in) such (pro)social performance-monitoring processes may help explain functional and social impairments across a wide range of clinical disorders. In this dissertation, we used various neuroimaging paradigms to examine subclinical and neurochemical influences on performance monitoring when errors had consequences for oneself or others. The studies in this dissertation indicate that neural performance-monitoring correlates are modulated by social, subclinical, and neurochemical factors, including social (responsibility) context, obsessive-compulsive symptoms, ovarian hormones, and pharmacological manipulations of dopamine and oxytocin. These findings have implications for the potential and utility of error-related brain activity as a clinical biomarker or endophenotype, our insight into social symptoms and impairments in obsessive-compulsive disorder, and for our understanding of the neurochemical mechanisms underlying performance monitoring. Show less
In my study I looked for a plausible cognitive theoretical framework for conforming behavior. The Theory of Event Coding (TEC) was the cognitive theory that offered a good basis for building this... Show moreIn my study I looked for a plausible cognitive theoretical framework for conforming behavior. The Theory of Event Coding (TEC) was the cognitive theory that offered a good basis for building this framework. I conducted an experiment using an existing study design adopted from previous studies of conformity adding a non-social condition where participants were confronted not with what they thought were other students’ choices but with random computer choices. According to TEC, a simple confrontation with an alternative behavior would affect reproduction of your own behavior at a later stage. The study results supported my theory. Unfortunately, the results were possibly influenced by Regression to the Mean. So I changed the study design to eliminate the issue. Also I wanted to see if and how conformity was affected by culture: collectivistic versus individualistic. This study was conducted partially in the lab (in the Netherlands and China) and partially online (in the USA and India). The results confirmed my initial hypothesis: the conformity effect did not differ across all experimental groups irrespective of the country or condition suggesting that people are sensitive to intervening events, but the social nature of these intervening events is irrelevant. Show less
In the realm of cognitive science, the quest to understand cognitive control has persisted for decades. Traditional notions of cognitive control have focused on inhibition through the prefrontal... Show moreIn the realm of cognitive science, the quest to understand cognitive control has persisted for decades. Traditional notions of cognitive control have focused on inhibition through the prefrontal cortex, but this dissertation challenges that perspective with a more comprehensive framework: The Metacontrol State Model (MSM). The MSM proposes that cognitive control emerges from the interplay between two opposing systems – one promoting flexibility and the other promoting persistence. These systems interact to shape our cognitive processing styles, thereby influencing our ability to effectively regulate our actions. This dissertation explores questions such as why individuals exhibit differences in cognitive control capacity and how state-related changes and trait-related predispositions impact cognitive control function. The overarching goal of this dissertation is to empirically test the MSM model and shed light on the factors that influence cognitive control. Through a series of experiments, it seeks to understand how altered states of consciousness, achieved through meditation techniques or serotonergic psychedelics, affect the balance between intentional and habitual processes. Additionally, it examines the extent to which individual trait biases serve as trans-diagnostic markers in various psychopathologies. This work comprises a literature review and six empirical articles. By integrating theory and empirical research, this dissertation takes us on a journey into the intricate world of cognitive control, shaping our understanding of how it influences our lives. Show less
This dissertation focuses on identifying neural mechanisms underlying social evaluations and self-views from a parent-adolescent perspective among adolescents with and without depression, and their... Show moreThis dissertation focuses on identifying neural mechanisms underlying social evaluations and self-views from a parent-adolescent perspective among adolescents with and without depression, and their parents. As part of RE-PAIR, affective and neural responses to praise and criticism about the adolescent child, and neural responses to reliving positive autobiographical memories were assessed, using ecologically valid fMRI-tasks. Particularly criticism seems to be highly salient to parents and adolescents, activating the salience network and decreasing mood. Both praise and reliving positive autobiographical memories activate areas important for self-referential processing in adolescents, which might reflect the ‘positive self’. Aberrant self-related processing when reliving autobiographical memories and increased sensitivity to parental criticism might be key underlying neural mechanisms in adolescent depression. By feeling more negatively, having more negative self-views, interpreting the environment as more negatively, memorizing past experiences in a more negative way, and focusing on negative events more often, adolescents with depression seem to have multiple negativity biases. These negativity biases are likely to negatively impact social relationships, potentially further reinforcing negative feelings and a negative self. Interventions exploring and strengthening the positive self, in particular the positive self aligning with the current self, might be useful for treating, or even preventing adolescent depression. Show less
Gerritsen, R.J.S.; Band, G.P.H.; Lafeber, J.; van den Beukel, N.; van Voskuilen, B.; Hoogland, R. 2023
Social anxiety is anxiety about negative evaluation and rejection by others. Social anxiety has been long related to reduced eye contact, this feature is seen as a casual and a maintaining factor... Show moreSocial anxiety is anxiety about negative evaluation and rejection by others. Social anxiety has been long related to reduced eye contact, this feature is seen as a casual and a maintaining factor of social anxiety disorder. However, related empirical findings were equivocal. The dissertation sought to address three key questions: (1) Whether social anxiety is featured by gaze avoidance. (2) Under which conditions socially anxious individuals display gaze avoidance. (3) To what extent subjective experience of gaze avoidance corresponds with actual gaze behavior. Using the combination of naturalistic social settings and wearable eye-trackers, the dissertation provides evidence for the relationship between social anxiety and gaze avoidance particularly in naturalistic social situation, and further reveals that the relationship depends on severity of social anxiety symptoms, type of social situation and age group. Besides, gaze anxiety is moderately associated with actual gaze avoidance. Altogether, the dissertation sheds light on the nature of gaze behavior adopted by socially anxious individuals in naturalistic social interactions. Show less
For people with chronic kidney disease (CKD), adhering to a range of self-management tasks—such as healthy eating, frequent physical activity, and non-smoking—is crucial. However, changing health... Show moreFor people with chronic kidney disease (CKD), adhering to a range of self-management tasks—such as healthy eating, frequent physical activity, and non-smoking—is crucial. However, changing health behaviors is difficult. To support patients in doing so, an eHealth care pathway was developed and evaluated. The results provide different insights into patients' priorities and care needs. Many individuals with CKD experience problems in self-management, which can be hindered by many different barriers of which a common one is psychological distress. Therefore, personalized interventions are needed with screening and treatment of both psychological distress and suboptimal self-management, tailored to the specific barriers and needs of the individual patient. The E-GOAL eHealth care pathway is an example of such a personalized intervention, combining cognitive behavioral therapy with self-management support. Patients were enthusiastic about the eHealth care pathway. However, in a randomized study, the intervention was not effective in reducing psychological distress compared with regular care only. Patients did experience improvements in areas of functioning and self-management that they prioritized themselves. These mixed results show that interventions could be implemented that are person-tailored, with personalized outcomes that reflect individually meaningful treatment goals and improvements for every patient. Show less
This thesis examines questions related to the prevalence of anxiety symptomatology and disorders in older adults, and compares two brief low-threshold psychological interventions (blended... Show moreThis thesis examines questions related to the prevalence of anxiety symptomatology and disorders in older adults, and compares two brief low-threshold psychological interventions (blended Acceptance and Commitment Therapy versus face-to-face Cognitive Behavioral Therapy) for older adults with anxiety symptoms in primary care. Show less
The overarching goal of this dissertation was to investigate parenting processes in relation to affective well-being in families in the daily flow of life from different perspectives (i.e.,... Show moreThe overarching goal of this dissertation was to investigate parenting processes in relation to affective well-being in families in the daily flow of life from different perspectives (i.e., adolescent, mother, father), on different levels (i.e., objective, momentary, and daily), and in a clinical sample (families with an adolescent with a depression) in addition to community samples. Our findings underline the importance of daily parental warmth and criticism of mothers and fathers for adolescents’ well-being. In addition, we showed that adolescents, parents, and their perceptions of parenting influence each other and that becoming more attuned to each other’s intention and needs is essential. Importantly, we consistently demonstrated that not only the extent and direction of the dynamic processes between parenting and affect in daily life differs between, but also within persons and families. This stresses the need for research focusing on individual processes and combining quantitative with qualitative measures. The use of more idiographic approaches would not only enable gaining more insight into these differences between individuals, but also contribute to identifying parenting practices that work for almost all adolescents. This would facilitate the development of interventions combining universal parenting principles with suggestions for tailoring it to individual- or family-specific situations. Show less
This dissertation reveals that sound financial decisions are determined by multiple factors and are germane to both financial satisfaction and financial well-being. The most promising factors to... Show moreThis dissertation reveals that sound financial decisions are determined by multiple factors and are germane to both financial satisfaction and financial well-being. The most promising factors to increase financial satisfaction were financial confidence, future orientation, and perceived behavioural control, and the most promising factors to increase financial well-being were the combination of high objective and high subjective financial knowledge and financial self-efficacy. We also found two observations remarkable. First, not all financial behaviours that could be intuitively regarded as positive were immediately beneficial to financial satisfaction or financial well-being. For example, budgeting and making considered purchases could be unpleasant and, therefore, adversely affect financial well-being in the short term. Likewise, adjusting spending based on changing (financial) circumstances and keeping track of expenses could be painful and, hence, adversely impacted financial satisfaction in the short term. Second, not all control skills that could be expected to help people make sound financial decisions, actually do so. For instance, people with more spending self-control reported working less toward their financial goals. It is possible that these people are so focused on curbing purchase impulses, that they forget what they are doing it for, namely to create financial room to achieve their goals. Show less
This thesis aimed to lay the foundation for a new set of Dutch mental health instruments to measure depression and anxiety in an efficient, reliable, valid, and responsive manner. More specifically... Show moreThis thesis aimed to lay the foundation for a new set of Dutch mental health instruments to measure depression and anxiety in an efficient, reliable, valid, and responsive manner. More specifically, the Dutch-Flemish PROMIS adult v1.0 item banks for Depression and Anxiety were psychometrically evaluated for computerized adaptive test (CAT) administration in the Dutch clinical and general population. CAT is a modern methodology that can be used to develop instruments that measure both efficiently and reliably as only the most appropriate questions are administered, and assessment terminates as soon as sufficient reliability is achieved. For the PROMIS CAT instruments, this was demonstrated in the thesis: measuring depression and anxiety in Dutch persons was highly efficient and reliable. Moreover, the CAT instruments were shown to measure depression and anxiety sufficiently responsive and valid as well. This even includes longitudinal validity, which has barely been studied for other Dutch mental health instruments. Overall, it was concluded that the new instruments are an improvement over available instruments. Therefore, using the PROMIS CAT instruments in clinical practice may lead to more efficient and reliable measurement that supports professionals and patients in evaluating patients' treatment. Show less
This dissertation describes the findings of six studies on mental health problems in the family context, specifically focusing on the associations with the parent-child relationship, parenting... Show moreThis dissertation describes the findings of six studies on mental health problems in the family context, specifically focusing on the associations with the parent-child relationship, parenting behaviors and experiences of childhood maltreatment. The aim is to better understand the risk factors, development and transmission of common psychological problems in order to contribute to prevention and treatment strategies for common psychological problems such as anxiety and depression.Overall, the findings underline the importance of the family context in the development and levels of mental health problems. In addition to the impact of one's own negative parenting experiences, including lack of warmth and experiences of emotional or physical abuse, negative parenting experiences of one's siblings are also associated with elevated anxiety and depressive symptom levels.We also found that externalizing problems of fathers and children have a negative impact on the parent-child interactions. In addition, we found that children with behavioral problems during early adolescence experience harsher parental discipline, even three years later.In the current treatment guidelines for common mental disorders, most therapies focus on the individual. An (additional) systemic approach and considering past and present family relationships in therapy, can be of additional value. For example, supporting families with interventions to improve the parent-child relationship can be helpful in the short and long term. Moreover, (early) treatment of psychological and behavioral problems of the parent or child might be beneficial for all family members. Show less
This PhD research dealt with neurobiological and behavioral aspects of pain. Previous research has demonstrated that pain sensitivity can be worsened as a result of learned negative expectations, a... Show moreThis PhD research dealt with neurobiological and behavioral aspects of pain. Previous research has demonstrated that pain sensitivity can be worsened as a result of learned negative expectations, a phenomenon termed nocebo hyperalgesia –a counterpart to placebo analgesia. This PhD dissertation describes neuroimaging and biobehavioral experimental studies as well as a review and a meta-analysis concerned with such learned effects on pain. The research adds to a growing literature that has been challenging antiquated understandings of pain as a bottom-up process. We conducted a series of biobehavioral studies to further our understanding of how bottom-up pain signaling can be influenced by top-down processing. We examined the types of experiences, such as receiving negative information or experiencing a negative effect first-hand, that may lead to stronger nocebo effects. Behavioral paradigms were used to model real-life pain experiences, through validated methods, novel learning manipulations, as well as a close examination of emotional correlates such as fear. Concurrently, innovative neuroscientific methods –including pharmacological manipulations– were used to examine the biobehavioral underpinnings of learned nocebo responses. Our findings add to the growing knowledgebase from the field of nocebo hyperalgesia, demonstrating that learning by experience can decisively influence the processing and perception of noxious stimuli. Show less
The current dissertation aims to assess the well-being of Emergency Department (ED) nurses and identify (combinations of) job factors related to this. Second, it aims to evaluate the overall... Show moreThe current dissertation aims to assess the well-being of Emergency Department (ED) nurses and identify (combinations of) job factors related to this. Second, it aims to evaluate the overall effectiveness and effective elements of an intervention implementation project conducted in multiple EDs in the Netherlands. Findings show a high prevalence of stress-related outcomes in ED nurses, but also high levels of work engagement and job satisfaction. Worktime demands and aggression/conflict situations have the strongest relationship with exhaustion, whilst work engagement is mostly related to developmental opportunities. Recovery during and outside of work can buffer the impact of patient-related stressful situations. According to a literature review, interventions can effectively prevent/reduce stress-related outcomes in nurses, with person-directed interventions reaching greater short-term effects. Little is known about their longevity and only a limited number of organization-directed studies exist. The current 2,5-year (mostly organization-directed) intervention project, led to improved working conditions but not (yet) to better well-being. Greater effects were found in hospitals with more fitting interventions and were employees felt more informed about and involved in the project. Psychosocial safety climate was positively related to communication, participation and the fit of actions to the risk factors, and as such provides a good starting point for a successful intervention project. Show less
What are the evolutionary roots of emotions? To answer this cardinal question, I study emotions in animals that are evolutionarily close to us: the great apes. In this dissertation, I investigated... Show moreWhat are the evolutionary roots of emotions? To answer this cardinal question, I study emotions in animals that are evolutionarily close to us: the great apes. In this dissertation, I investigated how bonobos, orangutans, and humans perceive emotions by studying three markers of emotion perception: attention, spontaneous mimicry, and implicit associations. Using touchscreen tasks and eye-tracking, I found that bonobos and humans share attentional mechanisms for perceiving their social surroundings. In both species, attention was immediately directed to emotional signals of unfamiliar others (in bonobos) or familiar others (in humans). Bonobos and humans also looked longer at certain emotionally-laden scenes than emotionally-neutral scenes. Subsequently, I studied orangutans: the only apes leading a semi-solitary existence. I found that orangutans show spontaneous mimicry in the form of contagious yawning and self-scratching, contradicting the idea that mimicry only occurs in highly social species. Finally, I created and validated a pictorial version of the implicit association test: a task that can potentially help us uncover whether apes have implicit associations with emotions. The results in this dissertation indicate a common evolutionary origin for attentional mechanisms and mimicry in great apes, including humans, and highlight the importance of considering species-specific characteristics that drive emotion perception. Show less
The overarching goal of this thesis was to examine the behavioral, computational, and neural mechanisms underlying social learning in adolescence. The first aim was to examine developmental... Show moreThe overarching goal of this thesis was to examine the behavioral, computational, and neural mechanisms underlying social learning in adolescence. The first aim was to examine developmental patterns across adolescence of two forms of social learning: (1) learning about other people, specifically, whether they are (un)cooperative and (un)trustworthy, and (2) learning for other people (prosocial learning) to know what actions may benefit or help others. I made use of multiple experimental paradigms based on well-known economic games and/or probabilistic reinforcement learning paradigms to assess these forms of social learning. Secondly, I aimed to examine underlying mechanisms and factors that account for age-related and individual differences in social learning. Applying computational modeling and functional neuroimaging as additional tools contributed to a better understanding of the underlying mechanisms and how these develop across adolescence. The findings in this thesis converge to early-to-mid adolescence as a key developmental period for developing well-adjusted social behaviors, and especially in the cooperative domain there are pronounced improvements. These studies make an important contribution to the literature on social development and learning, and may eventually contribute to interventions targeted at promoting well-adjusted behavior in typically developing adolescents, as well as youth with maladaptive social tendencies. Show less
