Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This... Show moreChinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects and the abandonment of those with adverse outcomes. By examining historical CMM specimens, particularly those in Dutch collections, tangible evidence of this evolution emerges.The Westhoff collection, spanning 140 years, reveals significant changes alongside enduring practices. A handwritten catalogue accompanying the collection aligns with modern CMM practices, indicating a remarkable continuity. Comparative analyses of historical collections and contemporary CMM in EU markets over three centuries emphasize the stability of core medicinal plant taxa. Additionally, the study validates the delayed luminescence (DL) technique for discerning CMM storage times, showing promising results.Despite challenges in preservation, historical CMM specimens offer unique insights into medicine's history, underscoring their importance for further research and understanding. Show less
The research presented here not only describes attempts to develop selective inhibitors for SENPs and PARK7 but also provides a chemical toolbox to study the function of PARK7. Both SENPs and PARK7... Show moreThe research presented here not only describes attempts to develop selective inhibitors for SENPs and PARK7 but also provides a chemical toolbox to study the function of PARK7. Both SENPs and PARK7 are attractive therapeutic targets for drug development. The results of the research and chemical tools described in this thesis will further aid in the development of more potent and selective inhibitors of SENPs and PARK7 for therapeutic purposes. Show less
