The role of Italian vernacular varieties in the history of communication in the Mediterranean world has only occasionally been investigated (see Baglioni 2010). In this research are brought to... Show moreThe role of Italian vernacular varieties in the history of communication in the Mediterranean world has only occasionally been investigated (see Baglioni 2010). In this research are brought to attention some letters exchanged between the States General of the United Provinces and the Ottoman Empire between the sixteenth and seventeenth centuries. They contribute to framing the spread of the Venetian variety as a lingua franca in diplomatic correspondence between the Mediterranean and Northern European worlds. Show less
In clinical research, associating dynamic time-varying covariates (e.g. biomarkers or drug assumption) with an event-time outcome represents a challenging task that could be tackled exploiting... Show moreIn clinical research, associating dynamic time-varying covariates (e.g. biomarkers or drug assumption) with an event-time outcome represents a challenging task that could be tackled exploiting Functional Data Analysis (FDA). In particular, FDA techniques can be used to represent dynamic time-varying covariates in terms of functions, which can be plugged into a Cox-type regression model to investigate the effect on survival outcomes. Data from MRC BO06/EORTC 80931 randomised controlled trial for treatment of osteosarcoma were analysed. Time-varying covariates related to alkaline phosphatase levels and chemotherapy dose during treatment were considered. Show less
