This article provides a synoptic view of research that has been carried out over the centuries on the fifteen languages that are spoken in the Ghana-Togo hills of West Africa with an outlier in... Show moreThis article provides a synoptic view of research that has been carried out over the centuries on the fifteen languages that are spoken in the Ghana-Togo hills of West Africa with an outlier in Benin. It traces the dilemmas and opportunities the languages offer for historical, descriptive and theoretical linguistics. It highlights some of the developments in the recent investigations that have taken place and concludes with an overview of the articles on GTM languages in the issue. Show less
-(4-methoxyphenyl)hydrazine-carbothioamide was described as a potential selective P-gp inhibitor that is not transported by P-gp. Therefore, the purpose of this study was to radiolabel two of its... Show more-(4-methoxyphenyl)hydrazine-carbothioamide was described as a potential selective P-gp inhibitor that is not transported by P-gp. Therefore, the purpose of this study was to radiolabel two of its analogues and to assess their potential for imaging P-gp expression using PET.\n across the blood-brain barrier was not altered by pre-treatment with the P-gp inhibitor tariquidar, and uptake was significantly lower in P-gp KO than in wild-type animals and indeed transported across the BBB or bound to P-gp in endothelial cells.\n appears to be a radiotracer that binds to P-gp, as showed in P-gp knock-out animals, but is not a substrate for P-gp.\nBackground\nResults\nConclusion Show less
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