This article provides a synoptic view of research that has been carried out over the centuries on the fifteen languages that are spoken in the Ghana-Togo hills of West Africa with an outlier in... Show moreThis article provides a synoptic view of research that has been carried out over the centuries on the fifteen languages that are spoken in the Ghana-Togo hills of West Africa with an outlier in Benin. It traces the dilemmas and opportunities the languages offer for historical, descriptive and theoretical linguistics. It highlights some of the developments in the recent investigations that have taken place and concludes with an overview of the articles on GTM languages in the issue. Show less
-(4-methoxyphenyl)hydrazine-carbothioamide was described as a potential selective P-gp inhibitor that is not transported by P-gp. Therefore, the purpose of this study was to radiolabel two of its... Show more-(4-methoxyphenyl)hydrazine-carbothioamide was described as a potential selective P-gp inhibitor that is not transported by P-gp. Therefore, the purpose of this study was to radiolabel two of its analogues and to assess their potential for imaging P-gp expression using PET.\n across the blood-brain barrier was not altered by pre-treatment with the P-gp inhibitor tariquidar, and uptake was significantly lower in P-gp KO than in wild-type animals and indeed transported across the BBB or bound to P-gp in endothelial cells.\n appears to be a radiotracer that binds to P-gp, as showed in P-gp knock-out animals, but is not a substrate for P-gp.\nBackground\nResults\nConclusion Show less
This article addresses the ways in which the Syrian author Khaled Khalifa describes and invokes feelings of shame as a literary strategy in the novel No Knives in the Kitchens of this City (2016).... Show moreThis article addresses the ways in which the Syrian author Khaled Khalifa describes and invokes feelings of shame as a literary strategy in the novel No Knives in the Kitchens of this City (2016). It argues that the author capitalizes on shame’s peculiarly unstable nature in expressing the unbearable subjugation to a system that is as brutal as it is banal under Syria’s president Hafez Al-Asad and later his son Bashar. Shame in this novel travels from character to character and from characters to readers in uncontrolled ways. The article teases out these trajectories in order to argue that the affective nature of shame is particularly suitable for addressing the conditions of living in Syria under the Asads. Show less