The purpose of this study is to discuss several aspects of facioscapulohumeral disease, also called "autosomal dominant facioscapulohumeral muscular dystrophy" or "Landouzy-Dejerine type of... Show moreThe purpose of this study is to discuss several aspects of facioscapulohumeral disease, also called "autosomal dominant facioscapulohumeral muscular dystrophy" or "Landouzy-Dejerine type of muscular dystrophy" or "Landouzy-Dejerine' s disease" . We consider this disorder well defined and recognizable, justifying the term facioscapulohumeral disease, abbreviated FSHD. Show less
De Kapsiki (Kameroen) en de Higi (Noordoost-Nigerie) vormen een etnische eenheid. De afzonderlijke benaming is een gevolg van externe politieke factoren. De auteur verrichtte... Show moreDe Kapsiki (Kameroen) en de Higi (Noordoost-Nigerie) vormen een etnische eenheid. De afzonderlijke benaming is een gevolg van externe politieke factoren. De auteur verrichtte cultureelantropologisch veldwerk onder dit volk. Hij beschrijft het en analyseert de structuur ervan. De geschiedenis van het gebied en de technisch-economische aanpassing van de Kapsiki/Higi zijn verantwoordelijk voor de atomisering van zijn samenleving. De auteur zoekt een antwoord op de vraag hoe een zo geatomiseerde samenleving als die van de Kapsiki/Higi kan functioneren Show less
Hemophilia is a sex linked, recessive, hereditary disorder characterizedby excessive bleeding. This bleeding tendency manifestsitself in spontaneous hemorrhages in the joint cavities and muscles... Show moreHemophilia is a sex linked, recessive, hereditary disorder characterizedby excessive bleeding. This bleeding tendency manifestsitself in spontaneous hemorrhages in the joint cavities and muscles,and in excessive bleeding after trauma or surgical procedures.The first written references to the disease can be found in theBabylonian Talmud, in which it can be read that Rabbi Judah thePatriarch exempted the third son from circumcision if his motherhad already lost two sons because they had bled to death afterthis operation ( 1 ) . Rabbi Simon hen Gamaliel even forbade a boyto be circumcised whien sons of his mother's three elder sisters haddied from bleeding after circumcision ( 2).In the 19th century Wardrop discovered the prolonged clottingtime of hemophilic blood. For a long time lack of prothrombin washeld responsible for the clotting defect until in 1935 Quick foundthat the prothrombin time of hemophilic plasma was normal ( 2) .Patek and Taylor reported in 1937 that the prolonged clottingtime of hemophilic plasma could be normalized by the addition ofa globulin fraction of normal blood. For this reason the lackingclotting component was called antihemophilic globulin; later, byinternational agreement, it was named clotting factor VIII (2).In 1944 Pavlovsky observed that a mixture of the blood of twohemophiliacs known to him had a normal clotting time ( 3, 4). Theright interpretation of this finding was given only in 1952 and notby Pavlovsky himself. In that year reports from New York, SanFrancisco, and Oxford described a disease which was clinically andgenetically undistinguishable from hemophilia, but the lackingclotting component was not factor VIII ( 5-7). The missing factorin this new disorder, PTC-deficiency, Christmas disease or hemophiliaB, was later called factor IX. Show less
In the first part of this essay the development of the study of African history is sketched, and the historical studies written by professional African historians from 1955 to 1972-3 are analysed.... Show moreIn the first part of this essay the development of the study of African history is sketched, and the historical studies written by professional African historians from 1955 to 1972-3 are analysed. Special attention is paid to the manisfestoes of the 1960s, programmatical declarations of what African history should be and how it should be written. Part two traces in detail what historical studis were actually produced in the fifteen years that followed independence in one particular West African country, Nigeria Show less
Focuses upon social interaction patterns in the Housing Estate of Kitale (Kenya). The inhabitants of this low income Housing Estate are sensitive to the same kind of spatial characteristics of... Show moreFocuses upon social interaction patterns in the Housing Estate of Kitale (Kenya). The inhabitants of this low income Housing Estate are sensitive to the same kind of spatial characteristics of housing as are people living under similar conditions in other societies. Both their economic and housing circumstances impose a strain on daily life. The inhabitants react to these circumstances by developing patterns of expectations and behaviour vis-…-vis their neighbours which resemble those of their counterparts elsewhere, despite the cultural and economic differences between societies Show less
Intestinal schistosomiasis is a disease caused by the tre-Schistosoma mansoni (Sambon, 1907). Man is the principal final host of this parasitic worm and the intermediate host is a fresh water snail... Show moreIntestinal schistosomiasis is a disease caused by the tre-Schistosoma mansoni (Sambon, 1907). Man is the principal final host of this parasitic worm and the intermediate host is a fresh water snail. The adult worms, which are some 8-15 mm long, inhabit the portal venous system. There, the females produce large amounts of eggs, many of which are excreted with the faeces. The remaining eggs get stuck in the tissues where they die. As a result of the dead eggs bilharzial granulomas are formed which are the main cause of pathologie changes in the host. The excreted eggs hatch on immersion in water and the escaping miracidia can freely live in the water for several hours. If they succeed in penetrating an intermediate host snail (in Ethiopia; Biomphalaria pfeifferi) a mother sporocyst, several daughter sporocysts, and eventually, after some 4-5 weeks, many cercariae are produced, The phase of asexual multiplication in the snail host results in the production of large numbers of exclusively either male or female cercariae. Only snails that have been penetrated successfully by several miracidia may shed cercariae of both sexes. The free living cercariae have a short life span: most of them die within 24 hours. Man may become infected when his skin is exposed to water containing cercariae. When the cercariae penetrate man's skin they are transformed into schistosomules and in some 40-60 days these schistosomules develop into adult worms that migrate to the portal and mesenteric veins. Then eggs are produced again. Show less
This thesis describes the tropic acid enzymes which in 4 steps catalyze the metabolic pathway of the alkaloid atropine. The enzymes have been discovered in a Pseudomonas bacterium from soil... Show moreThis thesis describes the tropic acid enzymes which in 4 steps catalyze the metabolic pathway of the alkaloid atropine. The enzymes have been discovered in a Pseudomonas bacterium from soil underneath the Atropa belladonna plant, the natural producer of atropine. These 4 enzymes are highly specific and show peculiar kinetics explained by the very asymmetrical equilibrium for step 2 and a keto-enol tautomerism for the product of step 2, the 2-phenylmalonic semialdehyde. The last part concerns the regulation of enzyme synthesis by product induction and its major advantage for cell economy. This thesis was written in the Dutch Language in 1969 and at that time deposited in the Repositorium of the Library of the Technical University, Delft, The Netherlands htpps://repository.tudelft.nl/view/tno; # 268336.Only in 2019 the thesis was translated by the author in English as precise copy nearly page by page of the 1969 version (no update). The English translation is only meant to disseminate the scientific data, described in the Dutch version. It does not intend to add any new data. In case of differences in the interpretation of the intellectual property only the Dutch version counts. Show less
This study describes the development of a method for the recognition and definition of leucocyte group Four. The method can also be applied to the detection of other leucocyte groups. Essential... Show moreThis study describes the development of a method for the recognition and definition of leucocyte group Four. The method can also be applied to the detection of other leucocyte groups. Essential factors in the method were: a) the use of leucocyte agglutinins formed during pregnancy; b) an insight into the shortcomings of the agglutination test; c) the use of statistical methods to overcome these shortcomings; and d) the use of a panel consisting of the leucocytes of the women who had formed the agglutinins, and of those of their husbands. This study describes the development of a method for the recognition and definition of leucocyte group Four. The method can also be applied to the detection of other leucocyte groups. Essential factors in the method were: a) the use of leucocyte agglutinins formed during pregnancy; b) an insight into the shortcomings of the agglutination test; c) the use of statistical methods to overcome these shortcomings; and d) the use of a panel consisting of the leucocytes of the women who had formed the agglutinins, and of those of their husbands. Show less
