The impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires... Show moreThe impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires hospital and/or ICU admission, results in prolonged and chronic illness, or leads to premature death. We aimed to quantify the total disease burden of acute COVID-19 in the Netherlands in 2020 using the disability-adjusted life-years (DALY) measure, and to investigate how burden varies between age-groups and occupations. Using standard methods and diverse data sources (mandatory notifications, population-level seroprevalence, hospital and ICU admissions, registered COVID-19 deaths, and the literature), we estimated years of life lost (YLL), years lived with disability, DALY and DALY per 100,000 population due to COVID-19, excluding post-acute sequelae, stratified by 5-year age-group and occupation category. The total disease burden due to acute COVID-19 was 286,100 (95% CI: 281,700-290,500) DALY, and the per-capita burden was 1640 (95% CI: 1620-1670) DALY/100,000, of which 99.4% consisted of YLL. The per-capita burden increased steeply with age, starting from 60 to 64 years, with relatively little burden estimated for persons under 50 years old. SARS-CoV-2 infection and associated premature mortality was responsible for a considerable direct health burden in the Netherlands, despite extensive public health measures. DALY were much higher than for other high-burden infectious diseases, but lower than estimated for coronary heart disease. These findings are valuable for informing public health decision-makers regarding the expected COVID-19 health burden among population subgroups, and the possible gains from targeted preventative interventions. Show less
Heus, E. de; Duijts, S.F.A.; Zwan, J.M. van der; Kapiteijn, E.; Dijkum, E.J.M.N. van; Herpen, C.M.L. van; Merkx, M.A.W. 2022
Introduction: Epidemiological discrepancies exist between rare and common can-cers. The aim of this population-based study was to compare rare versus common adult solid cancers in the Netherlands,... Show moreIntroduction: Epidemiological discrepancies exist between rare and common can-cers. The aim of this population-based study was to compare rare versus common adult solid cancers in the Netherlands, by providing incidence, prevalence and survival rates, evaluating trends in survival and comparing individual entities within domains and families.Methods: All adult patients with malignant solid cancers in the Netherlands between 1995 and 2019 were identified from the Netherlands Cancer Registry. Data on patient, tumour and treatment characteristics were collected, and relative survival and survival trends were ana-lysed.Results: A total of 170,628 patients with rare adult solid cancers and 806,023 patients with common adult solid cancers were included. Rare cancers accounted for 18% of all cancer di-agnoses (mean incidence), and 15% of the total ten-year cancer prevalence during 2010-2019. Overall 5-year survival was worse for rare cancers than for common cancers (52.0% versus 68.7%). Between 1995-1999 and 2015-2019, 5-year survival rates for rare cancers increased to a lesser extent (from 46.2% to 52.6%, i.e. 6.4%) than for common cancers (56.9% Show less
Osong, B.; Masciocchi, C.; Damiani, A.; Bermejo, I.; Meldolesi, E.; Chiloiro, G.; ... ; Soest, J. van 2022
Background and Purpose: Tumor recurrence, a characteristic of malignant tumors, is the biggest concern for rectal cancer survivors. The epidemiology of the disease calls for a pressing need to... Show moreBackground and Purpose: Tumor recurrence, a characteristic of malignant tumors, is the biggest concern for rectal cancer survivors. The epidemiology of the disease calls for a pressing need to improve healthcare quality and patient outcomes. Prediction models such as Bayesian networks, which can probabilistically reason under uncertainty, could assist caregivers with patient management. However, some concerns are associated with the standard approaches to developing these structures in medicine. Therefore, this study aims to compare Bayesian network structures that stem from these two techniques. Materials and Methods: A retrospective analysis was performed on 6754 locally advanced rectal cancer (LARC) patients enrolled in 14 international clinical trials. Local tumor recurrence at 2, 3, and 5-years was defined as the endpoints of interest. Five rectal cancer treating physicians from three countries elicited the expert structure. The algorithmic structure was inferred from the data with the hill-climbing algorithm. Structural performance was assessed with calibration plots and area under the curve values. Results: The area under the curve for the expert structure on the training and validation data was above 0.9 and 0.8, respectively, for all the time points. However, the algorithmic structure had superior predictive performance over the expert structure for all time points of interest. Conclusion: We have developed and internally validated a Bayesian networks structure from experts' opinions, which can predict the risk of a LARC patient developing a tumor recurrence at 2, 3, and 5 years. Our result shows that the algorithmic-based structures are more performant and less interpretable than expert based structures. Show less
This qualitative case study uses a life-course approach to explore syndemic vulnerability in a former fishing village in the Netherlands. Building on four years of fieldwork in a low-income... Show moreThis qualitative case study uses a life-course approach to explore syndemic vulnerability in a former fishing village in the Netherlands. Building on four years of fieldwork in a low-income neighborhood, we explored salient themes between and across families and generations. Elderly community members (> 65 years) were interviewed to map village history and explore how contextual factors have affected family life, health, and wellbeing since the 1940s. We systematically traced and compared processes leading to or from syndemic vulnerability by studying seven families across three generations. Adults with at least one of clustering diseases, their parents (when possible), and their children participated in semi-structured life-course interviews. A complex interaction of endemic social conditions, sociocultural normative processes, learned health be-haviors, and disheartening life events shaped families' predispositions for a syndemic of psychological distress, cardiometabolic conditions, and musculoskeletal pain. Educational attainment, continued social support, and aspirational capabilities emerged as themes related to decreasing syndemic vulnerability. This study demonstrates that syndemic vulnerability is potentially intergenerational and reveals the need for culturally sensitive and family-focused syndemic interventions. Future longitudinal research should focus on unravelling the pathogenesis of the clustering of psychological distress, cardiometabolic conditions, and musculoskeletal pain among young people. Show less
Bertus Haverkort groeide op in een boerengezin in Slagharen. Hij genoot van modernisering op de boerderij van zijn jeugd, omdat dit het werk verlichte en de opbrengsten verbeterde. Met in zijn... Show moreBertus Haverkort groeide op in een boerengezin in Slagharen. Hij genoot van modernisering op de boerderij van zijn jeugd, omdat dit het werk verlichte en de opbrengsten verbeterde. Met in zijn bagage een dosis moderne landbouwkennis uit Wageningen, werkte hij aan programma’s in de tropen waarbij overdracht van westerse kennis het doel was. De aanpak blijkt niet te werken. Hij plaatst vraagtekens bij de toepasbaarheid van de westerse kennis in situaties waar de ecologie, economie en cultuur zoveel verschillen. In samenwerking met lokale deskundigen uit India, Bolivia en Ghana wordt onderzocht hoe lokale wereldbeelden, waarden en kennis een rol spelen. Daarvoor wordt gewerkt aan een onderwijsmethode voor endogene ontwikkeling en aan een benadering voor co-creatie van wetenschappen uit verschillende tradities en wereldstreken. De internationale ervaringen worden in verband gebracht met de huidige crisis in de landbouw in Nederland en monden uit een pleidooi voor klimaat- en natuurvriendelijke landbouw. Show less
Jongenelen, R.G.L.; Leighton, T.; Veldkamp, F. 2022
Afscheidscollege van Prof. dr. Gert J. Oostindie Directeur van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde (KITLV-KNAW) Hoogleraar Koloniale en Postkoloniale Geschiedenis aan de... Show moreAfscheidscollege van Prof. dr. Gert J. Oostindie Directeur van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde (KITLV-KNAW) Hoogleraar Koloniale en Postkoloniale Geschiedenis aan de Universiteit Leiden uitgesproken op vrijdag 17 december 2021 Show less
Broecks, K.; Jack, C.; ter Mors E.; Boomsma, C.; Shackley, S. 2021
Carbon Capture and Storage at industrial processes (industrial CCS) is expected to play an important role in reducing industrial CO2 emissions in the short term. Industrial CCS involves capturing... Show moreCarbon Capture and Storage at industrial processes (industrial CCS) is expected to play an important role in reducing industrial CO2 emissions in the short term. Industrial CCS involves capturing CO2 from industrial processes, such as steel and cement making, and storing the CO2 underground. This study examined the public opinion of industrial CCS through an informed opinion survey in the Netherlands (N = 987) and the United Kingdom (UK; N = 974). On average, respondents were neutral to slightly positive about the implementation of industrial CCS in their country. UK respondents were slightly more positive (M = 4.66 on a 7-point scale) than Dutch respondents (M = 4.38). Awareness and perceived knowledge levels were somewhat higher in the Netherlands than in the UK. In both countries, perceived outcomes of industrial CCS (e.g. for climate change; safety; employment) were strongly associated with industrial CCS opinion, when compared to socio-demographics, proximity to industry (actual and perceived), and psychological variables. Differences between countries in outcome perceptions occur. For example, the safety of CO2 transport is a larger concern in the Netherlands than in the UK, while cost-control is a larger concern in the UK than in the Netherlands. These findings suggest that the national context for CCS implementation matters. Our research suggests that public engagement strategies will benefit from focusing on the economic and climate impacts of industrial CCS, as well as from building trust in industry and addressing perceived safety concerns surrounding different aspects of industrial CCS. Show less
Homicide is generally considered the most serious of all crimes and according to this line of reasoning, constitutes the “tip of the iceberg” of underlying crime. As such, homicide is frequently... Show moreHomicide is generally considered the most serious of all crimes and according to this line of reasoning, constitutes the “tip of the iceberg” of underlying crime. As such, homicide is frequently used as an indicator of the level of violence in cross-national and historical studies. The same could be said for drug-related homicide, specifically. Many drug-related violent incidents remain unreported – including torture, physical assault, threats and so on. In the absence of a full picture of the level of drug-related violence, it can be necessary to use other related indicators for which data is more readily available such as drug-related homicide (DRH). From this perspective, DRH would form a lethal tip of the iceberg of underlying drug-related criminal violence, which in turn could be an indicator of underlying drug market activity. If we indeed consider drug-related homicide as a tip of the iceberg of underlying criminal violence, then we would expect such homicides to cluster together in time and space with other types of criminal violence – in particular firearm-related homicides and other, non-lethal firearm incidents.In this working paper we seek to assess to what extent DRH cluster together with firearm- related violence and whether these forms of violence could be used as indicators of underling drug crime. Show less
This study describes how the interpretations, aspirations and school identity development of Islamic primary schools developed in the period 1988-2013. It gives an overview of the most important... Show moreThis study describes how the interpretations, aspirations and school identity development of Islamic primary schools developed in the period 1988-2013. It gives an overview of the most important turning points for Islamic education and how these turning points have influenced identity development.In this study, the administrators and directors of Islamic primary schools who have at least 10 years of experience in identity development are interviewed. This research shows how complex and diverse the identity of Islamic primary schools is. The main internal and external factors and actors that have influenced the development of school identity are discussed. National and international events have led to a social debate in which the role of Islamic primary schools regarding the integration of Muslims has been questioned. Partly because of this negative attention, Islamic schools have changed from introverted to extroverted organisations. This discussion has also led to unequal treatment of these schools. This research shows precisely how important these schools are for the emancipation of Muslims in the Netherlands. After all, Muslims themselves take the responsibility for education. Islamic primary schools are typical Dutch schools that make an important contribution to a safe pedagogical climate. Show less
Although the Netherlands remained neutral during the First World War, its population was nonetheless affected by the war. Already in the 1920s and 1930s, Dutch journalists wrote about the... Show moreAlthough the Netherlands remained neutral during the First World War, its population was nonetheless affected by the war. Already in the 1920s and 1930s, Dutch journalists wrote about the possibility of a war in which the Netherlands would also be involved. From the early 1920s to the German invasion in May 1940, journalists, political commentators, politicians, military officials and civilians were occupied by the question what tomorrow’s war might look like. This book captures their efforts and brings to life the cultural memories of the First World War and the expectations for the war to come.By focusing on the dynamics of cultural memories, predictions for the future, and the resultant fear and anxiety, this book provides a better understanding of the ways in which the cultural memories of the Great War and expectations for a future war were part of Dutch society. It draws from a wide array of sources, ranging from newspaper clippings, novels, films and theatre plays to political cartoons and paintings. Most importantly, this study has a unique perspective. Whereas most existing studies look back from the Second World War, this book instead looks forward from the interbellum. Show less
Studies of motivation in bilingual education settings often address questions of differences between learners in bilingual programmes and those in mainstream education. Problematic in this respect... Show moreStudies of motivation in bilingual education settings often address questions of differences between learners in bilingual programmes and those in mainstream education. Problematic in this respect is our increasing awareness of the inherent differences between these two learner groups, as learners in bilingual programmes have often chosen or been selected for a bilingual route (Mearns et al., 2017). The study presented here therefore does not seek to compare learners in bilingual and non-bilingual programmes, but rather to explore the nature of language learning motivation within the context of bilingual secondary education (BSE) in the Netherlands. Using a purpose-designed tool reflecting the L2 Motivational Self System (Dörnyei, 2009), this study investigated trends in motivation across genders, academic tracks and year-groups of nearly 2000 learners. Findings suggest that, although these learners all have bilingual education in common, differences between the motivations of these groups should not be overlooked. Show less
Background: Many countries organize population-based cervical cancer screening programs (CSP). In the Netherlands, eligible women are invited by mail. Marginalized women living in unstable... Show moreBackground: Many countries organize population-based cervical cancer screening programs (CSP). In the Netherlands, eligible women are invited by mail. Marginalized women living in unstable conditions and homeless women often fail to receive the invitation letter. These women also experience access barriers to regular healthcare. Consequently, despite presumably being at higher risk of developing cervical cancer due to prevalent risk factors, marginalized women are rarely screened for cervical cancer. The aim of the study was to identify the prevalence of (pre)cancerous abnormalities among marginalized women, and subsequently explore invitation approaches to enhance their screening participation.Methods: A cross-sectional intervention study was conducted in Rotterdam, the Netherlands. Between February and May 2019, marginalized women aged 20-60 years were invited to participate in cervical screening. A participant was considered screen-positive when they tested positive for high-risk human papilloma virus (HR-HPV) and showed cytological abnormalities. Data of the study population were compared with regional data of the Dutch CSP. Various invitation approaches were used to recruit women.Results: Out of 74 included women, 12 participants (16%) were found screen-positive, against 3.4% in women screened by the Dutch CSP. The prevalence ratio for the study population was 4.4 (95% CI 1.9-8.6) compared with women screened by the Dutch CSP. Using a direct, pro-active approach resulted in participation of 92% of the included women.Conclusion: Marginalized women have an increased risk of (pre)cancerous cervical abnormalities in screening, compared with women screened by the Dutch CSP. A direct pro-active approach was the most effective to stimulate screening participation. Enhancement of screening uptake for this population needs special effort. Show less
Jongenelen, R.G.L.; Veldkamp, F.; Yeadell-Moore, A. 2021
Between 1960 and 1983 the Dutch economist Dr. Albert Winsemius (1910-1996) was the most influential economic adviser to the government of Singapore and one of the leading architects of Singapore’s... Show moreBetween 1960 and 1983 the Dutch economist Dr. Albert Winsemius (1910-1996) was the most influential economic adviser to the government of Singapore and one of the leading architects of Singapore’s highly successful development model. Winsemius' beliefs and recommendations chimed with the views of Singapore’s first-generation postcolonial political leaders and quickly grew in popular appeal once they started yielding impressive economic results. Winsemius’ uncompromising hostility to communism, and at the same time his sympathy toward moderate trade unionism, were of particular importance here.This research identifies strategies and policies that contributed to Singapore's development, and that can be traced to Albert Winsemius as a historical principal. It concludes that in essence, many of these successful strategies and policies were based on Winsemius’ experiences in his earlier life and career: the economic reconstruction in the Netherlands in the years after World War Two, in which he played a key role, his empathy toward the United States and the American way of life, his contacts with other right-wing governments, and his involvement during the Cold War in the production of arms. Show less
Annually around 5 million people die as a consequence of injuries and many more suffer from livelong disabilities. Although implementation of trauma care systems and structured trauma training has... Show moreAnnually around 5 million people die as a consequence of injuries and many more suffer from livelong disabilities. Although implementation of trauma care systems and structured trauma training has led to decreased mortality and disability in several countries, controversies remain to exist. The awareness of the current trauma burden and its expected increase has led to new initiatives for scientific research in an attempt to eventually improve trauma care worldwide. Despite the improvements there is room for further optimization of care. The primary aim of this thesis is to analyze the presence and structure of trauma systems, evaluate specific care-delivery processes, and focus on patient-centered and clinically important parameters and outcomes. The second aim is to evaluate one of these parameters, the role of the nutritional status in the outcome of polytrauma patients. Show less
Article about Middle Iron Age (500-250 BC) cemeteries in the Southern- Netherlands, the Rhineland and Flanders. It presents an overview of the current state of research in this area. It is a first... Show moreArticle about Middle Iron Age (500-250 BC) cemeteries in the Southern- Netherlands, the Rhineland and Flanders. It presents an overview of the current state of research in this area. It is a first attempt to systematically review claims about the burial ritual based on a dataset of 67 sites. It discusses aspects of the burial ritual such as monument building, burial gifts and grave types. It also briefly discusses elite graves in the area. Show less
