This longitudinal study assessed the impact of the COVID-19 pandemic on children with autism spectrum disorder (ASD; n = 62; M-age = 13 years) by measuring emotional and behavioral problems before... Show moreThis longitudinal study assessed the impact of the COVID-19 pandemic on children with autism spectrum disorder (ASD; n = 62; M-age = 13 years) by measuring emotional and behavioral problems before and during the pandemic, and by comparing this change to a matched sample of children without ASD (n = 213; M-age = 16 years). Moreover, we examined whether indicators of parental well-being promoted resilience of children with ASD. Results showed that the mean change in problems did not differ between children with and without ASD. Importantly, some children showed an increase in problems, while others showed resilience. Parental well-being indicators were not related to resilience among children with ASD. The interindividual variability in responses, particularly among children with ASD, highlights the need for personalized support. Show less
Background: Self-care (SC) is a cornerstone in heart failure management and is related to patient outcomes. The continuous and complex demands of SC can be experienced as stressful and may require... Show moreBackground: Self-care (SC) is a cornerstone in heart failure management and is related to patient outcomes. The continuous and complex demands of SC can be experienced as stressful and may require patients to apply resilient behaviors as they manage their conditions. Resilience may be a helpful factor in performing SC.Objective: The aim of this study was to determine the association between resilience and SC in patients with heart failure.Methods: A cross-sectional study was performed between January 2020 and January 2021. Participants were asked to complete a questionnaire addressing baseline characteristics, the 2-item Patient Health Questionnaire, the Resilience Evaluation Scale, and the Self-Care of Chronic Illness Inventory, which measures 3 concepts of SC: SC maintenance, SC monitoring, and SC management. Multiple regression analysis was performed to determine whether resilience was associated with SC.Results: Eighty-six patients were included, and 74 patients completed the questionnaire. In the univariate analysis, an association was found between resilience and SC maintenance, resulting in an increase in SC for patients with higher resilience (β = 0.24; 95% confidence interval, 0.03-0.96). In the multivariate analysis adjusted and corrected for confounders, no significant associations between resilience and all SC scales were found.Conclusion: This study could not demonstrate significant associations between resilience and all SC scales. This study contributes to the body of knowledge on factors that can mediate or moderate SC. Further longitudinal research should be performed to study cause-effect relationships. Show less
Setroikromo, S.N.W.; Werff, S.J.A. van der; Smit, A.S.; Vermetten, E.; Wee, N.J.A. van der 2022
BackgroundInsights into the neurobiological basis of resilience can have important implications for the prevention and treatment of stress-related disorders, especially in populations that are... Show moreBackgroundInsights into the neurobiological basis of resilience can have important implications for the prevention and treatment of stress-related disorders, especially in populations that are subjected to high-stress environments. Evaluating large-scale resting-state networks (RSNs) can provide information regarding resilient specific brain function which may be useful in understanding resilience. This study aimed to explore functional connectivity patterns specific for (high) resilience in Dutch policemen after exposure to multiple work-related traumatic events. We investigated resting-state functional connectivity (RSFC) of the salience network (SN), limbic network, and the default-mode network (DMN). MethodsResting-state functional MRI scans were obtained from trauma-exposed executive personnel of the Dutch police force and non-trauma-exposed recruits from the police academy. Participants were divided into three groups: a resilient group (n = 31; trauma exposure; no psychopathology), a vulnerable group (n = 32; trauma exposure, psychopathology), and a control group (n = 19; no trauma exposure, no psychopathology). RSFC of the three networks of interest was compared between these groups, using an independent component analysis and a dual regression approach. ResultsWe found decreased resilience-specific positive RSFC of the salience network with several prefrontal regions. The DMN and limbic network RFSC did not show resilience-specific patterns. ConclusionThis study shows a differential RSFC specific for resilient police officers. This differential RSFC may be related to a greater capacity for internal-focused thought and interoceptive awareness, allowing more effective higher-order responses to stress in highly resilient individuals. Show less
Setroikromo, S.N.W.; Werff, S.J.A. van der; Smit, A.S.; Vermetten, E.; Wee, N.J.A. van der 2022
Background: Insights into the neurobiological basis of resilience can have important implications for the prevention and treatment of stress-related disorders, especially in populations that are... Show moreBackground: Insights into the neurobiological basis of resilience can have important implications for the prevention and treatment of stress-related disorders, especially in populations that are subjected to high-stress environments. Evaluating large-scale resting-state networks (RSNs) can provide information regarding resilient specific brain function which may be useful in understanding resilience. This study aimed to explore functional connectivity patterns specific for (high) resilience in Dutch policemen after exposure to multiple work-related traumatic events. We investigated resting-state functional connectivity (RSFC) of the salience network (SN), limbic network, and the default-mode network (DMN).Methods: Resting-state functional MRI scans were obtained from trauma-exposed executive personnel of the Dutch police force and non-trauma-exposed recruits from the police academy. Participants were divided into three groups: a resilient group (n = 31; trauma exposure; no psychopathology), a vulnerable group (n = 32; trauma exposure, psychopathology), and a control group (n = 19; no trauma exposure, no psychopathology). RSFC of the three networks of interest was compared between these groups, using an independent component analysis and a dual regression approach.Results: We found decreased resilience-specific positive RSFC of the salience network with several prefrontal regions. The DMN and limbic network RFSC did not show resilience-specific patterns.Conclusion: This study shows a differential RSFC specific for resilient police officers. This differential RSFC may be related to a greater capacity for internal-focused thought and interoceptive awareness, allowing more effective higher-order responses to stress in highly resilient individuals. Show less
Petzke, T.M.; Rodriguez-Girondo, M.; Meer, L.B. van der 2022
Background: A positive predictive genetic test for Huntington's disease (HD) can be a life-changing event for both carriers and their partners, leading to lower wellbeing and increasing the risk... Show moreBackground: A positive predictive genetic test for Huntington's disease (HD) can be a life-changing event for both carriers and their partners, leading to lower wellbeing and increasing the risk for separation and divorce. The 'Hold me Tight' program (HmT), based on emotionally focused couples' therapy, aims at strengthening the couple bond by targeting attachment needs.Objective: This study investigates whether the HmT program helps couples strengthen their relationship, as an investment in a future where the disease will affect life in many ways.Methods: In a multiple baseline design using three baselines of varying length, 15 couples of presymptomatic HD-carriers and their partners were included. In three consecutive groups, couples underwent the intervention (an adapted version of the 8-session HmT program) in four weekly sessions and completed self-report questionnaires throughout the study period of 19 weeks (17 measurements). Attachment style was assessed at baseline, resilience at baseline and at the end of the follow-up, while relationship satisfaction and wellbeing were measured weekly. A multi-level model was applied to the data.Results: Over the course of the study, wellbeing and relationship satisfaction significantly improved; resilience, however, did not. Furthermore, all three outcome measures were moderated by attachment style, with more securely attached individuals showing better outcomes.Conclusion: HmT improved wellbeing and relationship satisfaction of couples facing HD. Due to these improvements and high patient acceptability rates, this program could become a standardized procedure in HD care. The program could be adapted for other populations, e.g., couples facing other genetic neurological disorders. Show less
Objective: To explore putative different impacts of delayed graft function (DGF) on long-term graft survival in kidneys donated after brain death (DBD) and circulatory death (DCD).Background:... Show moreObjective: To explore putative different impacts of delayed graft function (DGF) on long-term graft survival in kidneys donated after brain death (DBD) and circulatory death (DCD).Background: Despite a 3-fold higher incidence of DGF in DCD grafts, large studies show equivalent long-term graft survival for DBD and DCD grafts. This observation implies a differential impact of DGF on DBD and DCD graft survival. The contrasting impact is remarkable and yet unexplained.Methods: The impact of DGF on DBD and DCD graft survival was evaluated in 6635 kidney transplants performed in The Netherlands. DGF severity and functional recovery dynamics were assessed for 599 kidney transplants performed at the Leiden Transplant Center. Immunohistochemical staining, gene expression profiling, and Ingenuity Pathway Analysis were used to identify differentially activated pathways in DBD and DCD grafts.Results: While DGF severely impacted 10-year graft survival in DBD grafts (HR 1.67; P < 0.001), DGF did not impact graft survival in DCD grafts (HR 1.08; P = 0.63). Shorter dialysis periods and superior posttransplant eGFRs in DBD grafts show that the differential impact was not caused by a more severe DGF phenotype in DBD grafts. Immunohistochemical evaluation indicates that pathways associated with tissue resilience are present in kidney grafts. Molecular evaluation showed selective activation of resilience-associated pathways in DCD grafts.Conclusions: This study shows an absent impact of DGF on long-term graft survival in DCD kidneys. Molecular evaluation suggests that the differential impact of DGF between DBD and DCD grafts relates to donor-type specific activation of resilience pathways in DCD grafts. Show less
In this conversation between trans scholar Eliza Steinbock and visual artist Cassils, they discuss the current state of culture wars against transgender rights, and how citizen artists can respond... Show moreIn this conversation between trans scholar Eliza Steinbock and visual artist Cassils, they discuss the current state of culture wars against transgender rights, and how citizen artists can respond to the waves of hate and violence. Cassils shares in detail how their performance and visual art methods pay homage to political artists who've come before, and how they incorporate resilience into their artmaking practice. Show less
Climate change has become one of the most pressing problems for both nature and human lives. Marine Protected Areas (MPAs) are part of a “natural solution” to climate change. Most of existing MPAs... Show moreClimate change has become one of the most pressing problems for both nature and human lives. Marine Protected Areas (MPAs) are part of a “natural solution” to climate change. Most of existing MPAs are governed by government agencies rather than private stakeholders such as NGOs, local communities and for-profit enterprises. Nevertheless, with the global push to create MPAs, the number of privately governed MPAs is expected to increase. In this context, this paper aims to investigate the role of private stakeholders in enhancing the governance effectiveness of MPAs so as to improve their capability to counter any adverse impact brought by the changing climate. After analysis, the strengths and weaknesses of the practice of each category of private stakeholders are uncovered and specific recommendations are proposed to promote the future practice. With the increasing number of privately governed MPAs in the future, this paper serves as a starting point and contributes to the literature on the study of the private governance of MPAs in the context of the changing climate. Show less
To adequately respond to crises, adaptive governance is crucial, but sometimes institutional adaptation is constrained, even when a society is faced with acute hazards. We hypothesize that economic... Show moreTo adequately respond to crises, adaptive governance is crucial, but sometimes institutional adaptation is constrained, even when a society is faced with acute hazards. We hypothesize that economic inequality, defined as unequal ownership of wealth and access to resources, crucially interacts with the way institutions function and are adapted or not. Because the time span for societal responses may be lengthy, we use the historical record as a laboratory to test our hypothesis. In doing so, we focus on floods and water management infrastructure. The test area is one where flood hazards were very evident—the Low Countries (present-day Netherlands and Belgium) in the premodern period (1300–1800)—and we employ comparative analysis of three regions within this geographical area. We draw two conclusions: first, both equitable and inequitable societies can demonstrate resilience in the face of floods, but only if the institutions employed to deal with the hazard are suited to the distributive context. Institutions must change parallel to any changes in inequality. Second, we show that institutional adaptation was not inevitable, but also sometimes failed to occur. Institutional adaptation was never inevitably triggered by stimulus of a hazard, but dependent on socio-political context. Even when vital for the community under threat, adaptation only tended to occur when the vested interests of those with wealth, resources, and power were directly hit. Show less
