Leiden University Scholarly Publications

Tummers, Q.R.J.G.; Hoogstins, C.E.S.; Gaarenstroom, K.N.; Kroon, C.D. de; Poelgeest, M.I.E. van; Vuyk, J.; ... ; Vahrmeijer, A.L. 2016

Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17

Article / Letter to editor

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Conclusions: FR alpha is a favorable target for fluorescence-guided surgery as EC17 produced a clear fluorescent signal in ovarian and breast cancer tissue. This resulted in resection of ovarian... Show moreConclusions: FR alpha is a favorable target for fluorescence-guided surgery as EC17 produced a clear fluorescent signal in ovarian and breast cancer tissue. This resulted in resection of ovarian cancer lesions that were otherwise not detected. Notwithstanding, autofluorescence caused false-positive lesions in ovarian cancer and difficulty in discriminating breast cancer-specific fluorescence from background signal. Optimization of the 500nm fluorophore, will minimize autofluorescence and further improve intraoperative tumor detection. Show less