This PhD thesis by Ulgu Arslan titled as “hiPSC-derived 3D cardiac microphysiological systems that can integrate immune and vascular components” explores culture conditions and their effects to... Show moreThis PhD thesis by Ulgu Arslan titled as “hiPSC-derived 3D cardiac microphysiological systems that can integrate immune and vascular components” explores culture conditions and their effects to incorporate human induced pluripotent stem cell derived macrophages in 3D cardiac microtissues; and endothelial cells to form vascularized and perfusable 3D cardiac microtissues on chips. It discusses and compares current state-of-the-art 3D microphysiological models with respect to their applications, readouts, limitations and possible implementation for their future use. Then, it establishes static microtissue or perfused organ-on-chip models with an emphasis on their potential to study microenvironmental cues, cellular crosstalk, disease modelling and drug testing in cardiovascular research. Show less
