This thesis addresses various aspects regarding the treatment of patients with early, active rheumatoid arthritis. The main conclusion of this thesis is that patients with RA benefit from... Show moreThis thesis addresses various aspects regarding the treatment of patients with early, active rheumatoid arthritis. The main conclusion of this thesis is that patients with RA benefit from combination therapy on the short-term, and the treat-to-target approach determines the success of the long-term outcomes. Following this strategy, high percentages of low disease activity and remission are achieved, and even drug-free remission has shown to be realistic outcome. As a result, functional ability remains stable over time (after improvement during the first year after initiating treatment), radiographic progression is limited in most patients and excess mortality was not observed. Show less
Buikhuisen, W.A.; Hiddingab, B.I.; Baas, P.; Meerbeeck, J.P. van 2015
After the implementation of standard first line chemotherapy with platinum and antifolates in pleural mesothelioma, patients are confronted with a need for second line treatment at relapse or... Show moreAfter the implementation of standard first line chemotherapy with platinum and antifolates in pleural mesothelioma, patients are confronted with a need for second line treatment at relapse or progression. We conducted a systematic review of the literature for the activity, effectiveness and toxicity of second line treatment. The results are presented according to the class of drugs: chemotherapy and targeted or biological agent. (C) 2015 Elsevier Ireland Ltd. All rights reserved. Show less
