Differentiated thyroid carcinoma (DTC) has favorable prognosis with high cure rate under treatment of thyroidectomy followed by radiotherapy. However, therapeutic efficiency decreases when... Show moreDifferentiated thyroid carcinoma (DTC) has favorable prognosis with high cure rate under treatment of thyroidectomy followed by radiotherapy. However, therapeutic efficiency decreases when dedifferentiation occurs. One of the purposes in this study is to use pharmaceuticals intervention to promote therapeutic responsiveness in thyroid carcinomas. Lithium compound and retinoid derivatives have been applied in thyroid cancer patients and in normal and thyroid cancer cell lines. The results indicate that Lithium compound doesn__t influence either iodine uptake in vivo and in vitro conditions or iodine efflux in cell lines observed. Retinoid, Bexarotene, slightly increases iodine uptake in thyroid cancer patients but does not reach the therapeutic level. In attempt to find efficient diagnostic markers, 156 patient samples including subsets of thyroid carcinomas and benign thyroid disorders have been investigated using immunohistochemistry in tissue micro-array sections. The results indicate that combination of protein expression of NIS, FN and Gal-3 may distinguish benign tumors from malignant thyroid carcinomas with high accuracy. As thyroid cancer patients have high survival rate, efficient and sensitive screening tool is crucial for follow up in DTC. In this study, thyroglobulin (Tg) of over 600 patients has been studies at unicenter with uniformed treatment. The results prove that multiple tests of Tg at fix time points may predict DTC prognosis and death. Show less
