In the thesis I present a series of studies that focus on the use and optimization of use of low-dose ketamine in clinical practice by:(1) reviewing the proof for its use in alleviation and... Show moreIn the thesis I present a series of studies that focus on the use and optimization of use of low-dose ketamine in clinical practice by:(1) reviewing the proof for its use in alleviation and prevention of acute and chronic (cancer and non-cancer) pain;(2) testing a possible novel administration route of ketamine, i.e. inhalation;(3) applying ketamine in a novel indication: the use of the S-enantiomer as respiratory stimulant during opioid-induced respiratory depression;(4) studying the effect of a nitric oxide donor on ketamine (the racemic and S-ketamine variants) typical side effects that hamper it’s use in chronic pain therapy Show less