Whose international matters, and why? How are geographic regions constructed? What are the channels of engagement between a place, its people, its institutions, and the world? How do we understand... Show moreWhose international matters, and why? How are geographic regions constructed? What are the channels of engagement between a place, its people, its institutions, and the world? How do we understand the non-West’s influence in contemporary global interactions? From humanitarianism and activism to diplomacy and institutional networks, South Asia has been a crucial place for the elaboration of international politics, even before the twentieth century. South Asia Unbound gathers an interdisciplinary group of scholars from across the world to investigate South Asian global engagement at the local, regional, national, and supra-national levels, spanning the time before and after independence. Only by understanding its past entanglements with the world can we understand South Asia’s increasing global importance today. Show less
In this thesis research is presented about the progressive muscle diseases Duchenne and Becker muscular dystrophy, two hereditary muscle diseases caused by a mutation in the gene coding for... Show moreIn this thesis research is presented about the progressive muscle diseases Duchenne and Becker muscular dystrophy, two hereditary muscle diseases caused by a mutation in the gene coding for dystrophin, a protein involved in muscle membrane stability. The first part describes the disease course of both diseases. It evaluates the effect of developments in care of Duchenne patients, improving age at wheelchair dependence and survival. Data are presented about the relatively mild disease course of selected Becker patients with a mutation that would be the result of exon skipping in a Duchenne patient, illustrating the possible result of this therapeutic approach. The second part of this thesis focusses on research into factors involved in disease variability. Data are presented regarding the role of dystrophin quantity in disease severity in Becker patients, showing no linear relationship. Expression of several dystrophin associated proteins is shown not to influence disease course either. Contrarily, a single nucleotide polymorphism in the LTBP4 gene involved in fibrosis and muscle regeneration is shown to influence disease severity. Lastly, a disease severity scale for Becker patients is presented in this thesis, enabling a better comparison of individual patients for the purpose of scientific research. Show less
SMALL Savannah is an Environmental Information System designed for the integrated analysis and sustainable land management in the savannas region of the Far North of Cameroon. This system combines... Show moreSMALL Savannah is an Environmental Information System designed for the integrated analysis and sustainable land management in the savannas region of the Far North of Cameroon. This system combines an observation and spatial analysis module for the representation of phenomena from various geographic data sources, with a module for the explanation and prediction of land use pattern and changes, and a dynamic modelling and simulation module for the exploration of possible land use change trajectories. Due to a high demographic pressure combined with an increasing human mobility, many changes have occurred in the land use of the study area during the last two decades. These dynamics have led to land saturation resulting in more competition between land uses and conflicts between actors. The spatial and quantitative analysis for the observation period (1987-1999) indicates that accessibility to the main urban centre, soil suitability and population pressure, have been the main driving factors behind this process. According to assumption formulated for future development, it is expected that changes in land use of this area will continue to depend on these factors. But, the land use trajectories will be mainly influenced by the implication of urban actors and the potential investment of local actors for improving land quality and management. The simulations performed for the period 1999 to 2010 indicate areas where changes are likely to occur, thus providing a possibility to evaluate the spatial impact of a given land management policy. The information system under development is an appropriate tool for a regional monitoring system of land use change and rural development. It can be used by scientist and actors involved in land use planning for decision making and adaptive land use management. Another utilisation can be considered with local actors in order to discuss and prepare any concertation or negotiation when dealing with participatory approach of land use and management. Show less
