A recently developed system-pharmacological model for the dynamics of receptor tyrosine kinases is used to compare di erent targets for drug action: one aiming at binding endogenous ligand needed... Show moreA recently developed system-pharmacological model for the dynamics of receptor tyrosine kinases is used to compare di erent targets for drug action: one aiming at binding endogenous ligand needed for phosphorylation and another binding re- ceptors at their kinase domains and thus preventing them to generate phosphory- lation. We obtain quantitative estimates for the e ectivity of the inhibitor which demonstrate the influence of drug-properties such as dose, a nity to target and drug-elimination rates. Show less
