eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support... Show moreeTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events. Show less
In this thesis, a collection of papers is put together dealing with various quantitative aspects of predictive modelling and archaeological prospection. Among the issues covered are the effects of... Show moreIn this thesis, a collection of papers is put together dealing with various quantitative aspects of predictive modelling and archaeological prospection. Among the issues covered are the effects of survey bias on the archaeological data used for predictive modelling, and the complexities of testing predictive models using both old and new archaeological data. Furthermore, an attempt is made to reconcile the worlds of expert judgment and quantitative analysis by means of multicriteria decision making techniques and Bayesian statistics. The thesis also offers some alternative approaches to predictive modelling, like using prehistoric land use reconstructions, and the integrating of social and cultural factors into the models. It also giv es an up to date review of the international and Dutch state of affairs in archaeological predictive modeling.. Show less
Verhagen, Jacobus Wilhelmus Hermanus Philippus 2007
Dutch archaeology has experienced profound changes in recent years. This has led to an increasing use of archaeological predictive modelling, a technique that uses information about the location of... Show moreDutch archaeology has experienced profound changes in recent years. This has led to an increasing use of archaeological predictive modelling, a technique that uses information about the location of known early human settlements to predict where additional settlements may have been located. Case Studies in Archaeological Predictive Modelling is the product of a decade of work by Philip Verhagen as a specialist in geographical information systems at RAAP Archeologisch Adviesbureau BV, one of the leading organizations in the field; the case studies presented here provide an overview of the field and point to potential future areas of research. Show less
