Retinopathy of prematurity (ROP) is the most important cause of vision loss premature infants. With a continuous growth in this vulnerable population, the number of newborns at risk for severe,... Show moreRetinopathy of prematurity (ROP) is the most important cause of vision loss premature infants. With a continuous growth in this vulnerable population, the number of newborns at risk for severe, sight threatening ROP increases. In this thesis the results of the national Dutch inventory on risk factors, screening, treatment and sequelae of ROP are presented. The principal aims of the study were to determine characteristics of newborns who are at highest risk to develop severe ROP to assess quality of screening and treatment and to evaluate the national ROP guideline. Following these studies together with extensive cost-effectiveness analyses, the current Dutch ROP screening and treatment guideline was adapted and implemented in November 2023. The NEDROP 2 allowed for more stringent screening inclusion criteria, lowering the number of infants that need to undergo burdensome screening under the precondition that no severe ROP would be missed. Annually, this will lower the screening costs by nearly 60,000 euros. Show less
Magnetic resonance imaging of the eye and orbit (MReye) is a cross-domain research field, combining (bio)physics, (bio)engineering, physiology, data sciences and ophthalmology. A growing number of... Show moreMagnetic resonance imaging of the eye and orbit (MReye) is a cross-domain research field, combining (bio)physics, (bio)engineering, physiology, data sciences and ophthalmology. A growing number of reports document technical innovations of MReye and promote their application in preclinical research and clinical science. Realizing the progress and promises, this review outlines current trends in MReye. Examples of MReye strategies and their clinical relevance are demonstrated. Frontier applications in ocular oncology, refractive surgery, ocular muscle disorders and orbital inflammation are presented and their implications for explorations into ophthalmic diseases are provided. Substantial progress in anatomically detailed, high-spatial resolution MReye of the eye, orbit and optic nerve is demonstrated. Recent developments in MReye of ocular tumors are explored, and its value for personalized eye models derived from machine learning in the treatment planning of uveal melanoma and evaluation of retinoblastoma is highlighted. The potential of MReye for monitoring drug distribution and for improving treatment management and the assessment of individual responses is discussed. To open a window into the eye and into (patho)physiological processes that in the past have been largely inaccessible, advances in MReye at ultrahigh magnetic field strengths are discussed. A concluding section ventures a glance beyond the horizon and explores future directions of MReye across multiple scales, including in vivo electrolyte mapping of sodium and other nuclei. This review underscores the need for the (bio)medical imaging and ophthalmic communities to expand efforts to find solutions to the remaining unsolved problems and technical obstacles of MReye, with the objective to transfer methodological advancements driven by MR physics into genuine clinical value. Show less
Purpose: To report the prevalence of honorary authorship (HA) among different journals in the ophthalmological literature Methods: An online survey was conducted among corresponding authors of six... Show morePurpose: To report the prevalence of honorary authorship (HA) among different journals in the ophthalmological literature Methods: An online survey was conducted among corresponding authors of six journals with the highest impact factors in the ophthalmological field. The survey consists of questions regarding (1) demographics, (2) awareness of authorship guidelines, and (3) application of authorship guidelines on their current surveyed article. Furthermore, respondents were asked if they felt that according to their understanding of the International Committee of Medical Journal Editors (ICMJEs) guidelines, a coauthor on their current article did not deserve authorship (perceived HA). Furthermore, respondents were asked if coauthors performed solely nonauthor tasks (ICMJE-defined HA). Results: Out of the 1688 surveys sent, 333 were returned, leading to a response rate of 19.7%. Eighty-four and a half percent of all respondents were aware of the ICMJE guidelines. When deciding on order of authorship, most authors decided as a group (43.8%), followed by the senior author deciding (30.1%), and 77 articles were decided by the first author (23.4%). When asked if respondents believed that any of their coauthors did not make sufficient contributions to be included as an author, 8.8% affirmed. One hundred and thirty-one respondents stated that any of their coauthors performed only one or more nonauthor tasks, making the rate of ICMJE-defined HA 39.8%. Conclusions: HA is present throughout all journals surveyed despite endorsement of the ICMJE guidelines by these same journals. The discrepancy between self-perceived HA and ICMJE-defined HA suggests the necessity for modifications to our authorship system or a contemporary revision to the ICMJE guidelines. Show less
Purpose To define unmet needs in ophthalmology which can realistically be addressed in the next years (2019-2025) and to describe potential avenues for research to address these challenges. Methods... Show morePurpose To define unmet needs in ophthalmology which can realistically be addressed in the next years (2019-2025) and to describe potential avenues for research to address these challenges. Methods Outcomes of a consensus process within the European Vision Institute (EVI, Brussels) are outlined. Disease areas which are discussed comprise glaucoma, retinal dystrophies, diabetic retinopathy, dry eye disease, corneal diseases, cataract and refractive surgery. Results Unmet needs in the mentioned disease areas are discussed and realistically achievable research projects outlined. Conclusion Considerable progress can be made in the field of ophthalmology and patient-relevant outcomes in the near future. Show less
Borm, C.D.J.M.; Werkmann, M.; Visser, F.; Peball, M.; Putz, D.; Seppi, K.; ... ; Vries, N.M. de 2019
