This thesis is focusing on cell-mediated induction of immune tolerance and consists of two parts. The studies described in Part I report the development of strategies for possible treatment of... Show moreThis thesis is focusing on cell-mediated induction of immune tolerance and consists of two parts. The studies described in Part I report the development of strategies for possible treatment of Inflammatory Bowel Diseases (IBD). Induction of immune tolerance, in IBD mouse model, with the use of regulatory T (Treg) cells generated in vitro by specific activation of naive T cells was achieved. Additionally Treg cells were also shown to be induced in vivo and restore intestinal immune tolerance with the use of adeno-associated virus (AAV) vector-based gene delivery. In relation to the use of AAV vector, Part II of this thesis is addressing the possibilities of tolerance induction to AAV capsid or transgene specific immune responses which can develop after AAV-based therapy Show less