Until the 17th century, the Dutch coastal region of Zeeland ranked among Europe's most urbanized areas, driven by thriving international trade networks. People living in this time of flourishing... Show moreUntil the 17th century, the Dutch coastal region of Zeeland ranked among Europe's most urbanized areas, driven by thriving international trade networks. People living in this time of flourishing economy benefitted enormously from it in terms of employment opportunities and working conditions, which were reportedly better than in the rest of the Low Countries. However, the rapid growth of Zeeland's urban centers likely presented increasing challenges for the population in terms of accessing essential resources, including food, clean water, and housing. In the 19th century, Zeeland's economy ultimately faced a significant downturn due to the decline in the maritime trade, leading to a substantial reduction in its urban population. Examining patterns of urbanization and economic histories that differ from the commonly studied thriving industrial contexts in bioarcheological research, as exemplified by Zeeland, is a crucial yet relatively underexplored facet in our efforts to understanding the human past. To address this gap, this study investigates the impact of urbanization on the health of Zeeland's inhabitants over time by analyzing nonspecific stress markers (i.e., cribra orbitalia, porotic hyperostosis, and linear enamel hypoplasia) and chronic maxillary sinusitis in a sample of 246 individuals from three urban sites dating from 1030 to 1800 CE. Our analysis of skeletal remains reveals significant differences in the prevalence of porotic hyperostosis, linear enamel hypoplasia, and sinusitis between the medieval and post-medieval periods. These findings suggest that de-urbanization and economic decline adversely affected the health and well-being of the populations under study, influenced by factors such as working conditions and food availability. This study provides a new perspective on bioarcheological approaches to urbanization, shedding light on the intricate realities of urbanization in Zeeland and offering important insights into its complexities. Show less
The African Studies Centre Leiden celebrated its 75th anniversary at Museum Volkenkunde in Leiden on 8 September 2022. It was a festive day with colleagues, students, alumni, and societal partners.... Show moreThe African Studies Centre Leiden celebrated its 75th anniversary at Museum Volkenkunde in Leiden on 8 September 2022. It was a festive day with colleagues, students, alumni, and societal partners. This ASCL Occasional Publication presents the keynote speeches of the day, giving insight into the Centre’s rich past and present research, education, library and societal activities. In addition, it is illustrated with many pictures of the day and showcases the ASCL Library’s special items from the collection that were exhibited. Show less
Casna, M.; Schats, R.; Hoogland, M.L.P.; Schrader, S.A. 2023
Since the opening of the first CLIL department in the Netherlands in 1989, tweetalig onderwijs (‘bilingual education’) has expanded into a national network of over 130 secondary schools, serving a... Show moreSince the opening of the first CLIL department in the Netherlands in 1989, tweetalig onderwijs (‘bilingual education’) has expanded into a national network of over 130 secondary schools, serving a population of around 37,000 learners. While academic interest in the field has also seen growth and diversification, the pace of practical developments and the lack of a structured research agenda have led to research becoming fragmented and lagging behind practice. This chapter provides an overview of the Dutch CLIL context followed by a critical review of research into organisation, implementation, outcomes and experiences in Dutch bilingual education. The chapter concludes with a reflection on the ways in which future research could support further developments in practice. Show less
Harkel, A.T. ten; Dierendonck, R. van; Farber, E.; Dee, M.; Doeve, P.; Hamerow, H.; ... ; Deckers, P. 2023
THIS PAPER ADDRESSES THE QUESTION, who were the people who were buried at the early medievalNorth Sea emporia? Conclusions about the mercantile character of the North Sea emporia are often based on... Show moreTHIS PAPER ADDRESSES THE QUESTION, who were the people who were buried at the early medievalNorth Sea emporia? Conclusions about the mercantile character of the North Sea emporia are often based on portablematerial culture. In recognition of the fact that it is difficult to draw conclusions about the identities of people basedon finds assemblages, two pilot projects have been completed that involved bioarchaeological analyses of cemetery pop-ulations associated with these sites. The first of these, the Investigating the Dead in Early Medieval Domburg project,undertook multi-disciplinary analyses of the (very small) surviving burial population from the mostly destroyed sitesin the Domburg area (Netherlands), combining isotope analysis, radiocarbon dating, biological anthropology, dendro-chronology, and provenancing and study of previous use of coffin wood. The second, the Medieval Migrants of theNorth Sea World project, inventoried available isotopic evidence for human remains from emporia sites in England,the Netherlands and Scandinavia, alongside contextual archaeological information. This paper presents both projects,providing the detailed information from Domburg in its wider, international context, and highlighting the need for acomprehensive research agenda to fill current gaps in our understanding of early medieval emporia populations. Show less
In 1727 the Dutch United East India Company (Verenigde Oostindische Compagnie, or VOC) ship Zeewijk wrecked in the Pelsaert Group of the Houtman Abrolhos Islands.This report details the methodology... Show moreIn 1727 the Dutch United East India Company (Verenigde Oostindische Compagnie, or VOC) ship Zeewijk wrecked in the Pelsaert Group of the Houtman Abrolhos Islands.This report details the methodology, outputs and conclusions of a 2022 field survey conducted between 11 and 17 March 2022. The primary aim was to create a 3D record of the Zeewijk (1727) shipwreck site using photogrammetry. The work would allow for a critical assessment of Mr Hugh Edwards’ claim of finding the wreck of Aagtekerke (1726) on the same site as Zeewijk. It would also better visualise the site for research, management, and public interpretation purposes. The fieldwork successfully mapped the widely dispersed Zeewijk shipwreck site on the inner (inside lagoon) and outer reef (in the surf zone) using digital cameras and GPS positioning. It resulted in significant new findings allowing a re-evaluation of the total count of all iron cannon and anchors in the offshore reef, and inshore lagoon areas.This work, when combined with findings of the earlier ‘Roaring Forties Project’ (Paterson et al. 2019), and more recent research undertaken by the Western Australian (WA) Museum, provides convincing evidence that there is only one shipwreck on the Zeewijk site, and negates the hypothesis of two VOC shipwrecks present within the Pelsaert Group. The resulting updated corpus of high-resolution digital imagery, 3D models and site data will greatly facilitate future studies, public interpretation outputs and on-going site monitoring and management of this highly significant Dutch-Australian mutual heritage site. It is gratefully acknowledged that the field work was primarily funded by a grant from the Embassy of the Kingdom of the Netherlands (GCE-2019-03), with additional funding support provided through the WA Museum/Australian Government’s Underwater Cultural Heritage Program and Flinders University’s Maritime Archaeology Program. Transport, logistics and local knowledge to enable safe access to the Zeewijk site were provided by the Liddon family. Show less
Background:Identification of risk factors and causes of stroke is key to optimize treatment and prevent recurrence. Up to one-third of young patients with stroke have a cryptogenic stroke according... Show moreBackground:Identification of risk factors and causes of stroke is key to optimize treatment and prevent recurrence. Up to one-third of young patients with stroke have a cryptogenic stroke according to current classification systems (Trial of ORG 10172 in Acute Stroke Treatment [TOAST] and atherosclerosis, small vessel disease, cardiac pathology, other causes, dissection [ASCOD]). The aim was to identify risk factors and leads for (new) causes of cryptogenic ischemic stroke in young adults, using the pediatric classification system from the IPSS study (International Pediatric Stroke Study).Methods:This is a multicenter prospective cohort study conducted in 17 hospitals in the Netherlands, consisting of 1322 patients aged 18 to 49 years with first-ever, imaging confirmed, ischemic stroke between 2013 and 2021. The main outcome was distribution of risk factors according to IPSS classification in patients with cryptogenic and noncryptogenic stroke according to the TOAST and ASCOD classification.Results:The median age was 44.2 years, and 697 (52.7%) were men. Of these 1322 patients, 333 (25.2%) had a cryptogenic stroke according to the TOAST classification. Additional classification using the ASCOD criteria reduced the number patients with cryptogenic stroke from 333 to 260 (19.7%). When risk factors according to the IPSS were taken into account, the number of patients with no potential cause or risk factor for stroke reduced to 10 (0.8%).Conclusions:Among young adults aged 18 to 49 years with a cryptogenic ischemic stroke according to the TOAST classification, risk factors for stroke are highly prevalent. Using a pediatric classification system provides new leads for the possible causes in cryptogenic stroke, and could potentially lead to more tailored treatment for young individuals with stroke. Show less
Jongenelen, R.G.L.; Leighton, T.; Veldkamp, F. 2023
The aim of this chapter is to contribute to the debate on deconstructing the gender binary, toexplore notions of experiencing shame and violence, and also to identify key points of self-concept... Show moreThe aim of this chapter is to contribute to the debate on deconstructing the gender binary, toexplore notions of experiencing shame and violence, and also to identify key points of self-concept ingenderqueer people, by running a survey in three different countries: Greece, the UK and the Netherlands.The survey is the first to explore the impact of this gender- binary discourse and the experience of shameand violence within this frame, within the genderaqueer community in a comparative perspective. Thechapter contributes to the debate on perceptions of masculinity and femininity in association with shameand violence, while reconnoitring the role of culture as a driver of these perceptions and how that role leadsto the re-evaluation of the self along with the sense and impact of shame as a relational process with the self and the society. The survey approaches shame and violence, not only in terms of how they are perceived by the genderqueer community, but also of how they are expressed, e.g. in a passive way (directed violence against a person) or active way (person as actor engaging in violent behaviour) in everyday life. The application of different perspectives on confronting the binary, power and shame provides a critical take on the gender-based debate and on the crux of self-concept and identifies breaks with existing thinking and practice that are essential to any reform of gender recognition policy. Show less
Jonas, P.; Savigne, E.G.; Koster, M.; Choonara, I. 2022
Over the past ten years, seven Dutch Universities have built a sustainable exchange with seven institutes in Cuban healthcare. The exchange was initiated by the Leiden University Medical Centre and... Show moreOver the past ten years, seven Dutch Universities have built a sustainable exchange with seven institutes in Cuban healthcare. The exchange was initiated by the Leiden University Medical Centre and the University of Medical Sciences of Havana. Cooperation with Cuba was chosen as Cuba has excellent primary healthcare and has a strong focus on prevention and public health. These were considered important due to the major contribution of non-communicable diseases to morbidity and mortality in the Netherlands. Exchanges have occurred with Dutch health professionals and students visiting Cuban healthcare institutions and Cuban postgraduate students studying in the Netherlands. There has been an increased awareness of the importance of public health and prevention in Dutch professional organizations following the exchange. The exchange has also helped to break the scientific and economic US blockade of Cuba and resulted in joint publications. In this review we described the process, key aspects, results and lessons learned in this process. Collaboration between Cuba (a middle income) and the Netherlands (a high-income country) is possible. Show less
The impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires... Show moreThe impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires hospital and/or ICU admission, results in prolonged and chronic illness, or leads to premature death. We aimed to quantify the total disease burden of acute COVID-19 in the Netherlands in 2020 using the disability-adjusted life-years (DALY) measure, and to investigate how burden varies between age-groups and occupations. Using standard methods and diverse data sources (mandatory notifications, population-level seroprevalence, hospital and ICU admissions, registered COVID-19 deaths, and the literature), we estimated years of life lost (YLL), years lived with disability, DALY and DALY per 100,000 population due to COVID-19, excluding post-acute sequelae, stratified by 5-year age-group and occupation category. The total disease burden due to acute COVID-19 was 286,100 (95% CI: 281,700-290,500) DALY, and the per-capita burden was 1640 (95% CI: 1620-1670) DALY/100,000, of which 99.4% consisted of YLL. The per-capita burden increased steeply with age, starting from 60 to 64 years, with relatively little burden estimated for persons under 50 years old. SARS-CoV-2 infection and associated premature mortality was responsible for a considerable direct health burden in the Netherlands, despite extensive public health measures. DALY were much higher than for other high-burden infectious diseases, but lower than estimated for coronary heart disease. These findings are valuable for informing public health decision-makers regarding the expected COVID-19 health burden among population subgroups, and the possible gains from targeted preventative interventions. Show less
Heus, E. de; Duijts, S.F.A.; Zwan, J.M. van der; Kapiteijn, E.; Dijkum, E.J.M.N. van; Herpen, C.M.L. van; Merkx, M.A.W. 2022
Introduction: Epidemiological discrepancies exist between rare and common can-cers. The aim of this population-based study was to compare rare versus common adult solid cancers in the Netherlands,... Show moreIntroduction: Epidemiological discrepancies exist between rare and common can-cers. The aim of this population-based study was to compare rare versus common adult solid cancers in the Netherlands, by providing incidence, prevalence and survival rates, evaluating trends in survival and comparing individual entities within domains and families.Methods: All adult patients with malignant solid cancers in the Netherlands between 1995 and 2019 were identified from the Netherlands Cancer Registry. Data on patient, tumour and treatment characteristics were collected, and relative survival and survival trends were ana-lysed.Results: A total of 170,628 patients with rare adult solid cancers and 806,023 patients with common adult solid cancers were included. Rare cancers accounted for 18% of all cancer di-agnoses (mean incidence), and 15% of the total ten-year cancer prevalence during 2010-2019. Overall 5-year survival was worse for rare cancers than for common cancers (52.0% versus 68.7%). Between 1995-1999 and 2015-2019, 5-year survival rates for rare cancers increased to a lesser extent (from 46.2% to 52.6%, i.e. 6.4%) than for common cancers (56.9% Show less
Osong, B.; Masciocchi, C.; Damiani, A.; Bermejo, I.; Meldolesi, E.; Chiloiro, G.; ... ; Soest, J. van 2022
Background and Purpose: Tumor recurrence, a characteristic of malignant tumors, is the biggest concern for rectal cancer survivors. The epidemiology of the disease calls for a pressing need to... Show moreBackground and Purpose: Tumor recurrence, a characteristic of malignant tumors, is the biggest concern for rectal cancer survivors. The epidemiology of the disease calls for a pressing need to improve healthcare quality and patient outcomes. Prediction models such as Bayesian networks, which can probabilistically reason under uncertainty, could assist caregivers with patient management. However, some concerns are associated with the standard approaches to developing these structures in medicine. Therefore, this study aims to compare Bayesian network structures that stem from these two techniques. Materials and Methods: A retrospective analysis was performed on 6754 locally advanced rectal cancer (LARC) patients enrolled in 14 international clinical trials. Local tumor recurrence at 2, 3, and 5-years was defined as the endpoints of interest. Five rectal cancer treating physicians from three countries elicited the expert structure. The algorithmic structure was inferred from the data with the hill-climbing algorithm. Structural performance was assessed with calibration plots and area under the curve values. Results: The area under the curve for the expert structure on the training and validation data was above 0.9 and 0.8, respectively, for all the time points. However, the algorithmic structure had superior predictive performance over the expert structure for all time points of interest. Conclusion: We have developed and internally validated a Bayesian networks structure from experts' opinions, which can predict the risk of a LARC patient developing a tumor recurrence at 2, 3, and 5 years. Our result shows that the algorithmic-based structures are more performant and less interpretable than expert based structures. Show less
This qualitative case study uses a life-course approach to explore syndemic vulnerability in a former fishing village in the Netherlands. Building on four years of fieldwork in a low-income... Show moreThis qualitative case study uses a life-course approach to explore syndemic vulnerability in a former fishing village in the Netherlands. Building on four years of fieldwork in a low-income neighborhood, we explored salient themes between and across families and generations. Elderly community members (> 65 years) were interviewed to map village history and explore how contextual factors have affected family life, health, and wellbeing since the 1940s. We systematically traced and compared processes leading to or from syndemic vulnerability by studying seven families across three generations. Adults with at least one of clustering diseases, their parents (when possible), and their children participated in semi-structured life-course interviews. A complex interaction of endemic social conditions, sociocultural normative processes, learned health be-haviors, and disheartening life events shaped families' predispositions for a syndemic of psychological distress, cardiometabolic conditions, and musculoskeletal pain. Educational attainment, continued social support, and aspirational capabilities emerged as themes related to decreasing syndemic vulnerability. This study demonstrates that syndemic vulnerability is potentially intergenerational and reveals the need for culturally sensitive and family-focused syndemic interventions. Future longitudinal research should focus on unravelling the pathogenesis of the clustering of psychological distress, cardiometabolic conditions, and musculoskeletal pain among young people. Show less
Bertus Haverkort groeide op in een boerengezin in Slagharen. Hij genoot van modernisering op de boerderij van zijn jeugd, omdat dit het werk verlichte en de opbrengsten verbeterde. Met in zijn... Show moreBertus Haverkort groeide op in een boerengezin in Slagharen. Hij genoot van modernisering op de boerderij van zijn jeugd, omdat dit het werk verlichte en de opbrengsten verbeterde. Met in zijn bagage een dosis moderne landbouwkennis uit Wageningen, werkte hij aan programma’s in de tropen waarbij overdracht van westerse kennis het doel was. De aanpak blijkt niet te werken. Hij plaatst vraagtekens bij de toepasbaarheid van de westerse kennis in situaties waar de ecologie, economie en cultuur zoveel verschillen. In samenwerking met lokale deskundigen uit India, Bolivia en Ghana wordt onderzocht hoe lokale wereldbeelden, waarden en kennis een rol spelen. Daarvoor wordt gewerkt aan een onderwijsmethode voor endogene ontwikkeling en aan een benadering voor co-creatie van wetenschappen uit verschillende tradities en wereldstreken. De internationale ervaringen worden in verband gebracht met de huidige crisis in de landbouw in Nederland en monden uit een pleidooi voor klimaat- en natuurvriendelijke landbouw. Show less
Jongenelen, R.G.L.; Leighton, T.; Veldkamp, F. 2022