Microvascular issues can precede major macrovascular diseases and their measurements can predict long-term cardiovascular disease and survival. Therefore, early interventions on microvascular... Show moreMicrovascular issues can precede major macrovascular diseases and their measurements can predict long-term cardiovascular disease and survival. Therefore, early interventions on microvascular issues can potentially delay later cardiovascular problems. Microcirculation is critical for tissue perfusion, exchange of nutrients, oxygen and carbon dioxide between blood and interstitial fluid, and in vascular homeostasis. Assessing the microcirculation is challenging due to spatially heterogeneous structure and variability in perfusion over time and under different conditions.The thesis aims to evaluate standardized techniques for investigating microcirculation. Although numerous techniques are used to assess microvasculature, there's no consensus on which is the most suitable for evaluating microcirculation. The dissertation also explores the possibilities and impossibilities of measuring the microvasculature for pharmacodynamic outcomes of new interventions and medications, and highlights the need for further research to develop effective interventions targeting microcirculation. Show less
This thesis evaluates the benefit and safety of the treatment of painful long-standing osteoporotic vertebral compression fractures with percutaneous vertebroplasty. In addition, benefit and safety... Show moreThis thesis evaluates the benefit and safety of the treatment of painful long-standing osteoporotic vertebral compression fractures with percutaneous vertebroplasty. In addition, benefit and safety were investigated for specific treatment indications, risk factors for the occurrence of the two most common adverse events were identified and methods for optimization of the timing and execution of the procedure were explored. Show less
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