Cortactine wordt gecodeerd door het gen EMS1 dat op het chromosoom 11q13 ligt. Het 11q13 gebied is geamplificeerd in een deel van de borsttumoren dat geassocieerd is met cortactine overexpressie en... Show moreCortactine wordt gecodeerd door het gen EMS1 dat op het chromosoom 11q13 ligt. Het 11q13 gebied is geamplificeerd in een deel van de borsttumoren dat geassocieerd is met cortactine overexpressie en de aanwezigheid van lymfeklier metastasen en een verhoogde sterfte. Cortactine is een F-actine bindend eiwit dat betrokken is bij de regulatie van het actine cytoskelet, dat belangrijk is bij cel migratie. Agnes van Rossum onderzocht de rol van cortactine (over)expressie op cel biologische processen die betrokken zijn bij de ontwikkeling en/of het gedrag van borstkanker. Zij ontdekte onder meer dat er cortactine varianten zijn die de cel migratie beïnvloeden. Verder lijkt cortactine een rol te spelen bij intercellulaire cel adhesie en cel spreiding. Een studie met cortactine transgene muizen toonde aan dat cortactine geen oorzakelijke rol heeft in het ontstaan van borstkanker. Van Rossum vermoedt dat cortactine de binding tussen cellen en hun omgeving dusdanig kan beïnvloeden dat deze gemakkelijker uit de oorspronkelijke tumor kunnen ontsnappen en gaan migreren. Show less
A poorly addressed women's issue in the early 1980s, 'human trafficking' is now high on the political agenda. Couched in the language of human and migrant rights and the depredations of... Show moreA poorly addressed women's issue in the early 1980s, 'human trafficking' is now high on the political agenda. Couched in the language of human and migrant rights and the depredations of transnational organised crime, anti-trafficking discourse describes the trafficker as the source and means of migrant exploitation in the global migration economy. Human trafficking, in the words of a G8 ministerial communiqué, is the 'dark side of globalisation'. Show less
The income gap between rich and developing countries is still the most influential factor driving transnational migration. Although strict border controls and selection criteria have erected... Show moreThe income gap between rich and developing countries is still the most influential factor driving transnational migration. Although strict border controls and selection criteria have erected barriers, thousands of people who do not meet the requirements have reached their destinations, while even greater numbers would like to do so. As individual effort cannot ensure successful cross-border migration, its brokerage has become a profitable business. Show less
On 14 March 2006 Australian newspaper The Age reported on a group of international students at Central Queensland University's Melbourne campus planning a hunger strike to protest being treated... Show moreOn 14 March 2006 Australian newspaper The Age reported on a group of international students at Central Queensland University's Melbourne campus planning a hunger strike to protest being treated like cash cows. The students, citing inadequate facilities, claimed CQU just wanted their money. While the strike was called off as students feared cancellation of their visas, the matter is far from settled. Show less
Thangjam Manorama was openly critical of the Armed Forces Special Powers Act. On 11 July 2004 she was arrested and then allegedly raped, tortured and murdered by members of the counter-insurgency... Show moreThangjam Manorama was openly critical of the Armed Forces Special Powers Act. On 11 July 2004 she was arrested and then allegedly raped, tortured and murdered by members of the counter-insurgency group Assam Rifles. The latter claimed Manorama was a People's Liberation Army sympathiser and was killed while trying to escape custody. Women's and civil liberties organisations, however, claimed her death was one more episode in the history of state-sanctioned violence against women in the border regions of northeast India. Show less
Located at a strategic Asian crossroads, Burma (Myanmar) is one of the world's most ethnically diverse countries. Surrounded by Bangladesh, China, India, Laos and Thailand, it is also one of the... Show moreLocated at a strategic Asian crossroads, Burma (Myanmar) is one of the world's most ethnically diverse countries. Surrounded by Bangladesh, China, India, Laos and Thailand, it is also one of the most strife-torn and lawless along its 3,650-mile border. Its post-colonial experience exemplifies how illicit economies, insurgent or military-based politics and cross-border human movement can flourish in the wake of failed attempts to create a modern nation-state. Show less
