Prosocial behavior and empathy are important aspects of developing social relations in childhood. Prior studies showed protracted structural development of social brain regions associated with... Show moreProsocial behavior and empathy are important aspects of developing social relations in childhood. Prior studies showed protracted structural development of social brain regions associated with prosocial behavior. However, it remains unknown how structure of the social brain is influenced by genetic or environmental factors, and whether overlapping heritability factors explain covariance in structure of the social brain and behavior. The current study examined this hypothesis in a twin sample (aged 7-9-year; N = 512). Bilateral measures of surface area and cortical thickness of the medial prefrontal cortex (mPFC), temporo-parietal junction (TPJ), posterior superior temporal sulcus (pSTS), and precuneus were analyzed. Results showed genetic contributions to surface area and cortical thickness for all brain regions. We found additional shared environmental influences for TPJ, suggesting that this region might be relatively more sensitive to social experiences. Genetic factors also influenced parent-reported prosocial behavior (A = 45%) and empathy (A = 59%). We provided initial evidence that the precuneus shares genetically determined variance with empathy, suggesting a possible small genetic overlap (9%) in brain structure and empathy. These findings show that structure of the social brain and empathy are driven by a combination of genetic and environmental factors, with some factors overlapping for brain structure and behavior. Show less
Michelle Achterberg is a developmental neuroscientist with an interest in social emotional development. In her thesis, Michelle provides a comprehensive overview of the underlying mechanisms of... Show moreMichelle Achterberg is a developmental neuroscientist with an interest in social emotional development. In her thesis, Michelle provides a comprehensive overview of the underlying mechanisms of social emotion regulation in childhood. Her studies show that the brain is prone to signal for socially relevant information. She revealed that the network of social saliency is already present in childhood, indicating that this might be a core social mechanism.The thesis additionally shows that social rejection is often followed by behavioral aggression, and regulation of these retaliation emotions is related to control mechanisms of the dorsolateral prefrontal cortex. Moreover, the results show that the vast architecture of functional subcortical-prefrontal brain connectivity is already in place in middle childhood and suggest fine tuning of (social evaluation) brain networks across childhood. These findings highlighting the need to incorporate childhood into developmental models of social emotion regulation.Neuroimaging research, specifically neuroimaging in children is prone to challenges and several methodological considerations need to be taken into account when studying the childhood brain. In spite of these difficulties, studying childhood brain development has the potential to provide important insights into a unique developmental window of opportunity. Show less
Verhees, M.W.F.T.; Ceulemans, E.; Bakermans-Kranenburg, M.J.; IJzendoorn, M.H. van; De Winter, S.; Bosmans, G. 2017
