The chapters that comprised this thesis cover a broad range of subjects from analytical method development to clinical application of metabolic profiling. They are united by the facts that all of... Show moreThe chapters that comprised this thesis cover a broad range of subjects from analytical method development to clinical application of metabolic profiling. They are united by the facts that all of these studies aimed at analysis of biological fluids and that the presented methods and approaches may ultimately become parts of a robust metabolomics workflow that might be used in a future personalized medicine. Show less