Self-perceived word-finding difficulties are common in aging individuals as well as in Alzheimer's Disease (AD). Language and speech deficits are difficult to objectify with neuropsychological... Show moreSelf-perceived word-finding difficulties are common in aging individuals as well as in Alzheimer's Disease (AD). Language and speech deficits are difficult to objectify with neuropsychological assessments. We therefore aimed to investigate whether amyloid, an early AD pathological hallmark, is associated with speech-derived semantic complexity. We included 63 individuals with subjective cognitive decline (age 64 ± 8, MMSE 29 ± 1), with amyloid status (positron emission tomography [PET] scans n = 59, or Aβ1-42 cerebrospinal fluid [CSF] n = 4). Spontaneous speech was recorded using three open-ended tasks (description of cookie theft picture, abstract painting and a regular Sunday), transcribed verbatim and subsequently, linguistic parameters were extracted using T-scan computational software, including specific words (content words, frequent, concrete and abstract nouns, and fillers), lexical complexity (lemma frequency, Type-Token-Ratio) and syntactic complexity (Developmental Level scale). Nineteen individuals (30%) had high levels of amyloid burden, and there were no differences between groups on conventional neuropsychological tests. Using multinomial regression with lin- guistic parameters (in tertiles), we found that high amyloid burden is associated with fewer concrete nouns (ORmiddle (95%CI): 7.6 (1.4–41.2), ORlowest: 6.7 (1.2–37.1)) and content words (ORlowest: 6.3 (1.0–38.1). In addition, we found an interaction for education between high amyloid burden and more abstract nouns. In conclusion, high amyloid burden was modestly associated with fewer specific words, but not with syntactic complexity, lexical complexity or conventional neuropsychological tests, suggesting that subtle spontaneous speech deficits might occur in preclinical AD. Show less
Accent Building is a course book that introduces the vowels and consonants as well the most important stress and intonation patterns of British English. Through small chunks of information and... Show moreAccent Building is a course book that introduces the vowels and consonants as well the most important stress and intonation patterns of British English. Through small chunks of information and short analysis and repetition exercises, students are, in a step-by-step fashion, urged to build their English accent. The target is understandable, natural and educated English. The tips and exercises aim primarily at making learners aware of the nature of sounds, and this course gives them the opportunity to practise their knowledge by listening to and imitating native speakers of English. A website with recordings of words, sentences and texts is part of this course. Furthermore, learners gain access to an online tool which measures the acoustics of their pronunciation and compares it with those of a native speaker model. By the end of the course, students will not only have improved their own pronunciation; they will also be more confident when teaching others English pronunciation at an advanced level. Show less
Schrijven op berkenbast speelde in de middeleeuwen een wezenlijke rol in de communicatie en sociale organisatie van verschillende Russische steden, met name de stad Novgorod, gelegen ten zuiden van... Show moreSchrijven op berkenbast speelde in de middeleeuwen een wezenlijke rol in de communicatie en sociale organisatie van verschillende Russische steden, met name de stad Novgorod, gelegen ten zuiden van het huidige Sint-Petersburg. Dit boek laat aan de hand van een selectie van overgeleverde berkenbastbrieven zien hoezeer de schrijftraditie geïntegreerd was in het dagelijks leven. De korte mededelingen doen ons vaak denken aan hedendaagse e-mails of sms'jes. Ze waren bedoeld voor alledaagse communicatie over geld en macht, afspraken en conflicten, management en huishouden, ellende en liefde. Stemmen op berkenbast offers a compilation of personal letters written on birchbarck. It is an introduction to medieval communication in Russian Novgorod. BIC HB Show less
The Rubáiyát by the Persian poet ‘Umar Khayyæm (1048-1131) is used in contemporary Iran as a resistance literature, symbolizing the secularist voice in cultural debates. While Islamic... Show moreThe Rubáiyát by the Persian poet ‘Umar Khayyæm (1048-1131) is used in contemporary Iran as a resistance literature, symbolizing the secularist voice in cultural debates. While Islamic fundamentalists criticize Khayyæm as an atheist and materialist philosopher who questions God’s creation and the promise of reward or punishment in the hereafter, secularist intellectuals see in him an example of a scientist who scrutinizes the mysteries of the world. Others see a spiritual master, a Sufi, who guides people to the truth. This volume collects eighteen essays on the history of the reception of ‘Umar Khayyæm in various literary traditions, exploring how his philosophy of doubt, carpe diem, hedonism, and in vino veritas has inspired generations of poets, novelists, painters, musicians, calligraphers and film-makers. Show less
