Leiden University Scholarly Publications

Trietsch, M.D.; Oonk, M.H.M.; Hawinkels, L.J.A.C.; Bor, R.; Eendenburg, J.D.H. van; Ivanova, Z.; ... ; Bosse, T. 2016

Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas

Article / Letter to editor

open access

Conclusion: This is the first study to show high L1CAM-expression at the infiltrating margin of VSCC's. L1CAM-expressing VSCCs had a significantly worse prognosis compared to L1CAM-negative tumours... Show moreConclusion: This is the first study to show high L1CAM-expression at the infiltrating margin of VSCC's. L1CAM-expressing VSCCs had a significantly worse prognosis compared to L1CAM-negative tumours. The highest expression was observed in spindle-shaped cells, where it might be correlated to their invasive capacity. Show less