Objectives: A significant proportion of patients with pancreatic cancer are over the age of 70 years. The aim was to compare treatment and survival for older patients with pancreatic cancer treated... Show moreObjectives: A significant proportion of patients with pancreatic cancer are over the age of 70 years. The aim was to compare treatment and survival for older patients with pancreatic cancer treated throughout the Netherlands or Moffitt Cancer Center (Tampa, Florida).Methods: All age-eligible patients with pancreatic adenocarcinoma (2008-2012) were identified. Results were stratified by stage. Treatment (neoadjuvant, surgery, adjuvant and palliative treatment) and short-term survival were compared, and where appropriate adjusted (sex, age, grade, year) or stratified according to age or hospital (Netherlands-academic, teaching, non-teaching).Results: In total, 2728 patients were included. Neo-adjuvant chemoradiation was more often administered at Moffitt (non-metastatic stages), as was adjuvant chemoradiation and chemotherapy (p <.001). The proportion surgery was not significantly different. In patients with advanced disease, more patients at Moffitt underwent palliative chemotherapy (64.5% versus 17.4%; p < .001). Short-term survival was better among Moffitt patients (HR 0.30 (95%CI 0.11-0.82), HR 0.56 (0.41-0.72), HR 0.43 (0.36-0.52) for early, T3 or node positive and advanced). Differences were less pronounced comparing Dutch academic hospitals to Moffitt.Conclusion: In the present comparison, a treatment regimen as delivered at Moffitt was associated with prolonged short-term survival. Further detailed analyses of selection criteria for systemic treatment could lead to tailored treatment and improved outcomes. (C) 2019 Elsevier Ltd. All rights reserved. Show less
Breugom, A.J.; Bastiaannet, E.; Boelens, P.G.; Eycken, E. van; Iversen, L.H.; Martling, A.; ... ; Velde, C.J.H. van de 2018
This dissertation reports on the beliefs and perceptions of Chinese and Dutch university teachers regarding the role of research in university teaching and how these beliefs and perceptions can be... Show moreThis dissertation reports on the beliefs and perceptions of Chinese and Dutch university teachers regarding the role of research in university teaching and how these beliefs and perceptions can be explained by their cultural, institutional and individual background characteristics. Different aspects of their beliefs and perceptions were explored via a survey study and an in-depth interview study. In general, the Chinese and Dutch teachers were found to be surprisingly similar. Both groups highly valued the integration of research into teaching for student learning, and particularly valued the fostering of critical disposition. Both groups perceived less actual integration of research into their current teaching practices, which indicates a major gap between the ideal and actual. Despite these widespread similarities, some intriguing differences were also found in the interview study. The Chinese teachers were more explicit on the assessment and control of student process, and largely aimed at the attainment of competencies, which can better prepare the student for a future career. In contrast, the Dutch teachers frequently mentioned providing emotional support and posing questions to students as ways to monitor student progress, and aimed more at fostering student well-being and student interest in research. Show less
Prins, M.; Meadows, G.; Bobevski, I.; Graham, A.; Verhaak, P.; Meer, K. van der; ... ; Bensing, J. 2011
