This thesis describes the potential use of these cardiac progenitor-derived extracellular vesicles (EVs) for cardiac repair and focused on translational aspects that could accelerate clinical... Show moreThis thesis describes the potential use of these cardiac progenitor-derived extracellular vesicles (EVs) for cardiac repair and focused on translational aspects that could accelerate clinical implementation of EV-based therapeutics. The first steps have been made in optimizing EV production processes such as EV isolation and storage. Furthermore, this thesis described a potential method for sustained EV release and to prolong therapeutic exposure by using a hydrogel. Ultimately, this could contribute to improved efficacy upon local delivery of EV therapeutics. Together, this thesis potentially contributes to fasten clinical adoption of EV-based therapeutics for patients with heart failure. Show less
