Purpose: Both the resting heart rate (RHR) and the callous-unemotional (CU) traits have been associated with juvenile delinquency, however the effect of their interaction is not yet clear.Methods:... Show morePurpose: Both the resting heart rate (RHR) and the callous-unemotional (CU) traits have been associated with juvenile delinquency, however the effect of their interaction is not yet clear.Methods: Four hundred and twenty-three institutionalized adolescents divided into early adolescents (10-14 years, n = 133), late adolescents (15-17 years, n = 286), and young adults (18-22 years, n = 136) participated in the study. RHR was measured using a wristband, and CU traits and delinquency history were assessed using self-reported questionnaires. Moderation analysis was performed to understand how the combination between RHR and CU is associated to offending.Results: CU traits were associated with offending at all ages. The interactions between RHR and CU traits were significantly related to the likelihood of offending in the early and the late adolescent. The highest likelihood of offending is related to high CU traits combined with low RHR in early adolescents and with high RHR in late adolescents.Conclusions: These findings provide further insight in the relationship between psychopathic traits and bio-physiological maturation in explaining juvenile delinquency. Show less
Introduction: Recent reports have raised concerns of cardiorespiratory deterioration in some infants receiving respiratory support at birth. We aimed to independently determine whether respiratory... Show moreIntroduction: Recent reports have raised concerns of cardiorespiratory deterioration in some infants receiving respiratory support at birth. We aimed to independently determine whether respiratory support with a facemask is associated with a decrease in heart rate (HR) in some late-preterm and term infants. Methods: Secondary analysis of data from infants born at & GE;32(+0) weeks of gestation at 2 perinatal centres in Melbourne, Australia. Change in HR up to 120 s after facemask placement, measured using 3-lead electrocardiography, was assessed every 3 s until 60 s and every 5 s thereafter from video recordings. Results: In the 15 s after facemask placement, 10/68 (15%) infants had a decrease in mean HR by >10 beats per minute (bpm) compared with their individual baseline mean HR in the 15 s before facemask placement. In 4 (6%) infants, HR decreased to <100 bpm. Nine out of 68 (13%) infants had an increase in mean HR by >10 bpm; 7 of these infants had a baseline HR <120 bpm. In univariable comparisons, the following characteristics were found not to be risk factors for a decrease in HR by >10 bpm: prematurity; type of respiratory support; hypoxaemia; early cord clamping; mode of birth; HR <120 bpm before mask placement. Six out of 63 infants (10%) who had HR & GE;120 bpm after facemask placement had a late decrease in HR to Conclusion: Facemask respiratory support at birth is temporally associated with a decrease in HR in a subset of late-preterm and term infants. Show less
Social anxiety disorder (SAD) is the extreme fear and avoidance of one or more social situations. The goal of the current study was to investigate whether heart rate variability (HRV) during... Show moreSocial anxiety disorder (SAD) is the extreme fear and avoidance of one or more social situations. The goal of the current study was to investigate whether heart rate variability (HRV) during resting state and a social performance task (SPT) is a candidate endophenotype of SAD. In this two-generation family study, patients with SAD with their partner and children, and their siblings with partner and children took part in a SPT (total n = 121, 9 families, 3-30 persons per family, age range: 8-61 years, 17 patients with SAD). In this task, participants had to watch and evaluate the speech of a female peer, and had to give a similar speech. HRV was measured during two resting state phases, and during anticipation, speech and recovery phases of the SPT. We tested two criteria for endophenotypes: co-segregation with SAD within families and heritability. HRV did not co-segregate with SAD within families. Root mean square of successive differences during the first resting phase and recovery, and high frequency power during all phases of the task were heritable. It should be noted that few participants were diagnosed with SAD. Results during the speech should be interpreted with caution, because the duration was short and there was a lot of movement. HRV during resting state and the SPT is a possible endophenotype, but not of SAD. As other studies have shown that HRV is related to different internalizing disorders, HRV might reflect a transdiagnostic genetic vulnerability for internalizing disorders. Future research should investigate which factors influence the development of psychopathology in persons with decreased HRV. Show less
Posterror slowing (PES) is the observation that people respond slower on trials subsequent to error commissions than on trials subsequent to correct responses. Different accounts have been proposed... Show morePosterror slowing (PES) is the observation that people respond slower on trials subsequent to error commissions than on trials subsequent to correct responses. Different accounts have been proposed to explain PES. On the one hand, it has been suggested that PES arises from an adaptive increase in cognitive control following error commission, thereby making people more cautious after making an error. On the other hand, PES has been attributed to an orienting response, indicating that attention is shifted toward the error. In the present study we tested these accounts by investigating the effects of error commission in both flanker and switch tasks on two task-evoked cardiac measures: the interbeat interval—that is, the interval between two consecutive R peaks—and the RZ interval—that is, the interval between the R peak and the Z point—as measured using electro- and impedance cardiography, respectively. These measures allowed us to measure cardiac deceleration (autonomic orienting) and cardiac effort mobilization, respectively. Our results revealed a shorter RZ interval during posterror trials, indicating increased effort mobilization following errors. In addition, we replicated earlier studies that have shown cardiac slowing during error trials. However, multilevel analyses showed that only the posterror decrease in RZ interval predicted posterror reaction times, whereas there was no positive relationship between error-related cardiac deceleration and posterror reaction times. Our results suggest that PES is related to increased cardiac effort, supporting a cognitive-control account of PES. Show less
The goal of this dissertation was to delineate psychophysiological endophenotypes of social anxiety disorder. We conducted a unique two-generation family study, including patients with social... Show moreThe goal of this dissertation was to delineate psychophysiological endophenotypes of social anxiety disorder. We conducted a unique two-generation family study, including patients with social anxiety disorder, their partner and children, and their siblings with partner and children. This dissertation focused on EEG and heart rate measures during resting state, a social performance task and a social judgment paradigm. In the social performance task, participants watched and evaluated a speech of a female peer and then gave a speech in front of a video camera themselves. In the social judgment paradigm, participants received social acceptance or rejection feedback, after indicating their expectations about the upcoming feedback. This dissertation focused on three criteria for endophenotypes: association with SAD, co-segregation with SAD within families, and heritability. Delta-beta correlation during anticipation of a stressful social situation, and N1 and P3 amplitude in the social judgment paradigm are candidate endophenotypes of SAD. Show less
Schoorl, J.; Rijn, S. van; De Wied, M.; Goozen, S.H.M. van; Swaab, J.T. 2017
Although mortality in old age has significantly decreased over the last fifty years in the developed world, there still remains a large inter-individual variability in ageing trajectories,... Show more Although mortality in old age has significantly decreased over the last fifty years in the developed world, there still remains a large inter-individual variability in ageing trajectories, morbidity and mortality. In the three parts of this thesis, we examined three interacting systems that have been identified as contributing to a slower pace of ageing, namely glucose/insulin metabolism (part I), the thyroid axis (part II), and the autonomic nervous system (part III). We found that familial longevity is associated with a stronger association of insulin parameters with microstructural brain parameters, and by higher TSH secretion, in the absence of differences in basal energy metabolism or differences in heart rate and its variability. Using specialized MRI techniques, we showed that subtle changes in microstructural brain parenchymal homogeneity in relation to insulin can be detected, even in brain tissue that appears normal on conventional MR imaging sequences. Insulin (rather than glucose), seemed to be a stronger indicator of micro- structural brain integrity in normo-glycemic older adults. Furthermore, intranasal application of insulin improved brain perfusion in parietal and occipital gray matter and in the thalamus of older adults. These results deepen our understanding of the physiological mechanisms and processes that underlie the ageing process. Show less
Current evidence on older adults is derived from population-based cohort studies and randomized controlled trials, which may not include frail individuals. Data are lacking on older outpatients, a... Show moreCurrent evidence on older adults is derived from population-based cohort studies and randomized controlled trials, which may not include frail individuals. Data are lacking on older outpatients, a potentially diverse population. Therefore, we initiated the Milan Geriatrics 75+ Cohort Study, a prospective hospital-based outpatient cohort study. Chapter 1 of this thesis provides a background on the controversies regarding the homeostasis of older adults. Chapter 2, 3 and 4 report findings from the Milan Geriatrics 75+ Cohort Study. Chapter 2 explores the association between blood pressure and cognition, and whether it varies according to age and functional status. Chapter 3 examines the relationship between blood pressure and mortality risk, and whether it varies according to functional and cognitive status. Chapter 4 investigates the association between thyroid status and mortality risk in euthyroid older adults, and whether it differs by sex and age. Chapter 5 and 6 report findings from the PROSPER cohort, which includes older adults at high cardiovascular risk. Chapter 5 presents new evidence on the association of heart rate and heart rate variability with functional decline. Chapter 6 analyses the relationship between blood pressure variability and functional decline. Chapter 7 summarises and discusses the main findings of this thesis. Show less
Long-term stability of individual differences in stress responses has repeatedly been demonstrated in adults, but few studies have investigated the development of stability in adolescence. The... Show moreLong-term stability of individual differences in stress responses has repeatedly been demonstrated in adults, but few studies have investigated the development of stability in adolescence. The present study was the first to investigate the stability of individual differences in heart rate, parasympathetic (RMSSD, pNN50, HF), sympathetic (LF/HF, SC), and HPA-axis (salivary cortisol) responses in a youth sample (8–19 years). Responses to public speaking were measured twice over 2 years. Stability was moderate for absolute responses and task delta responses of HR, RMSSD, pNN50, and HF. Stability was lower for SC and task delta responses of LF/HF and cortisol. Anticipation delta responses showed low stability for HR and cortisol. The latter was moderated by age or puberty, so that individual differences were more stable in more mature individuals. The results support the suggestion that stress responses may be reset during adolescence, but only for the HPA axis. Show less
Self-control abilities are crucial for successful functioning in daily life. At the core of self-control lies the ability to intentionally inhibit one__s actions. Intentional inhibition differs... Show moreSelf-control abilities are crucial for successful functioning in daily life. At the core of self-control lies the ability to intentionally inhibit one__s actions. Intentional inhibition differs from externally driven inhibition in that it is driven by an internal thought process rather than an external stimulus that tells one to stop. The goal of this thesis was to examine the development of intentional inhibition and compare this with externally driven inhibition. In order to investigate the covert process of intentional inhibition, the research described in this thesis made use of neurobiological measures such as phasic heart rate changes and functional magnetic resonance imaging (fMRI). In addition, to learn more about self-control in context, the final empirical chapter examined intentional and externally driven inhibition in the context of relevant and irrelevant emotions. Show less
Koopman Jacob J.E.; Bodegom David van; Maan Arie C.; Li Zhao; Ziem Juventus B.; Westendorp Rudi G.J.; Jukema J.Wouter 2015
A high heart rate and a low heart rate variability at rest are established predictors of various forms of functional impairment, morbidity, and mortality [1–6]. Two explanations can be given for... Show moreA high heart rate and a low heart rate variability at rest are established predictors of various forms of functional impairment, morbidity, and mortality [1–6]. Two explanations can be given for these associations. On one hand, a high heart rate and a low heart rate variability are thought to reflect dysfunction of the flexible autonomic regulation of the heart rate in particular and of the body's functioning in general that arises during ageing [3–5]. On the other hand, a high heart rate and a low heart rate variability are brought about by cardiovascular risk factors, such as obesity, hyperlipidaemia, diabetes, hypertension, and physical inactivity [2,3,7–9]. Since research on heart rate and heart rate variability has almost exclusively been conducted in western populations with an affluent sedentary lifestyle and high prevalences of these risk factors, it has been difficult to determine whether or not heart rate and heart rate variability are associated with functional impairment, morbidity, and mortality independently of cardiovascular risk factors. Show less
Cardiovascular safety issues related to changes in blood pressure, arise frequently in drug development. In the thesis __Towards predictive cardiovascular safety __ a systems pharmacology approach_... Show moreCardiovascular safety issues related to changes in blood pressure, arise frequently in drug development. In the thesis __Towards predictive cardiovascular safety __ a systems pharmacology approach__, a system-specific model is described to quantify drug effects on the interrelationship between mean arterial pressure, cardiac output, heart rate, stroke volume and total peripheral resistance in rats. The developed model can be used to quantify and predict the dynamic changes in the cardiovascular system (CVS) and elucidate the mechanism of action of novel compounds. An ultimate application of this system-specific CVS model would be to facilitate the anticipation of the clinical response based on preclinical data for newly developed compounds. Furthermore, the developed system-specific CVS model was combined with receptor models to quantify and predict the cardiovascular effects of the sphingosine 1-phosphate (S1P) receptor agonists, fingolimod-phosphate (fingolimod-P)and siponimod, in rats. This systems pharmacology model provided a quantitative understanding of the cardiovascular effects of fingolimod-P and siponimod and can be applied to predict the cardiovascular effects of other S1P receptor agonists with different selectivity profiles in rats. Ultimately, it may constitute a basis for prediction of cardiovascular effects of S1P receptor agonists in humans Show less
