Cytomegalovirus (CMV) infection is the most common congenital viral infection worldwide. The symptom of congenital CMV infection encountered most frequently is sensorineural hearing loss, which... Show moreCytomegalovirus (CMV) infection is the most common congenital viral infection worldwide. The symptom of congenital CMV infection encountered most frequently is sensorineural hearing loss, which will affect approximately one out of __ve congenitally infected newborns. Because of the late-onset nature of the hearing loss, up to half of the children with congenital CMV-related hearing loss may not be detected in the newborn hearing screening. This thesis addresses several aspects of congenital CMV infection in general and more specifically in the Netherlands, in order to determine the necessity and feasibility of newborn screening for congenital CMV. Show less
This is the first time developmental outcome following hearing screening in children with permanent childhood hearing impairment was studied in a unique, pseudo-randomized design. We found that... Show moreThis is the first time developmental outcome following hearing screening in children with permanent childhood hearing impairment was studied in a unique, pseudo-randomized design. We found that early detection of hearing loss by newborn hearing screening (and subsequent early intervention) is beneficial for the development of children with permanent childhood hearing impairment, although their development at 3-5 years is not yet comparable to that of children with normal hearing. We showed that the yield of the current hearing screening program is large, but that there is ample room for improvement in the timing following early detection of hearing loss. We would like to emphasize that the aetiology of permanent childhood hearing impairment should be investigated and the cause taken into account when evaluating the development of the child. Show less
The cochlear implant (CI) gives severely hearing impaired to profoundly deaf children access to auditory speech input and consequently stimulates their oral language development. However, speech... Show moreThe cochlear implant (CI) gives severely hearing impaired to profoundly deaf children access to auditory speech input and consequently stimulates their oral language development. However, speech perception with a CI is still not optimal. Therefore, these children develop oral language based on reduced auditory speech input. This dissertation aims at enhancing our knowledge of whether a CI provides sufficient access to auditory speech input to acquire verbal morphology. It takes a new perspective regarding the research on morphology acquisition in CI children. The outcomes of the children under investigation are not only compared to those of their normal hearing peers, but also to those of their specific language impaired (SLI) peers. The latter group is known to be particularly delayed in their acquisition of verbal morphology. One of the major findings of this dissertation is that CI children outperform their SLI peers in the production of verbal morphology. Remarkably, they are even able to catch up with their normal hearing peers. Nevertheless, their spontaneous speech samples contain more verb inflection errors as compared to similar samples from normal hearing peers. In this respect CI children compare to their SLI peers. The results of the CI children are further analyzed as a function of their age at implantation and hearing age. Additional emphasis is given to the role of perceptual salience in the acquisition of morphology. Show less
