This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central... Show moreThis thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study. In short, I study the details of immune defenses during embryonic development of basal hexapods in Chapter 2, the trade-off with developmental speed in Chapter 3, and the genetic basis of developmental speed in Chapter 4, using selection lines of the red flour beetle Tribolium castaneum. I demonstrate that 1) springtail eggs do show an immune response, despite absence of a serosa that provides immune protection to insect eggs; 2) a strong trade-off is present between developmental speed and fecundity in the selection lines of the beetle T. castaneum; and 3) a life-history allele of large effect shortens developmental time in this wild insect population. I suggest that such alleles of large effect play a crucial role when insects have to adapt their developmental speed to current climate change. Show less
Sheltering is an immediate human need and determines well-being andhealth. However, we face many challenges in providing homes and offices for allon this rapidly changing planet. In the 21st... Show moreSheltering is an immediate human need and determines well-being andhealth. However, we face many challenges in providing homes and offices for allon this rapidly changing planet. In the 21st century, climate change, resourcecrises, and population expansion will combine to exacerbate existingchallenges. We need to better understand and tackle these issues. Therefore,the overarching research question of this thesis is: What are the mainchallenges and opportunities in delivering decent shelters for nearly 10billion people in a warming and resource-scarce world? To this end, this thesismakes the first steps in exploring several key intersecting challenges relatedto resources scarcity, global warming, and natural hazards. Show less
Climate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has... Show moreClimate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has demonstrated how global crises can arise suddenly and have a significant impact on public health. Global warming, a chronic process punctuated by acute episodes of extreme weather events, is an insidious global health crisis needing at least as much attention. Many neurological diseases are complex chronic conditions influenced at many levels by changes in the environment. This review aimed to collate and evaluate reports from clinical and basic science about the relationship between climate change and epilepsy. The keywords climate change, seasonal variation, temperature, humidity, thermoregulation, biorhythm, gene, circadian rhythm, heat, and weather were used to search the published evidence. A number of climatic variables are associated with increased seizure frequency in people with epilepsy. Climate change-induced increase in seizure precipitants such as fevers, stress, and sleep deprivation (e.g. as a result of more frequent extreme weather events) or vector-borne infections may trigger or exacerbate seizures, lead to deterioration of seizure control, and affect neurological, cerebrovascular, or cardiovascular comorbidities and risk of sudden unexpected death in epilepsy. Risks are likely to be modified by many factors, ranging from individual genetic variation and temperature-dependent channel function, to housing quality and global supply chains. According to the results of the limited number of experimental studies with animal models of seizures or epilepsy, different seizure types appear to have distinct susceptibility to seasonal influences. Increased body temperature, whether in the context of fever or not, has a critical role in seizure threshold and seizure-related brain damage. Links between climate change and epilepsy are likely to be multifactorial, complex, and often indirect, which makes predictions difficult. We need more data on possible climate-driven altered risks for seizures, epilepsy, and epileptogenesis, to identify underlying mechanisms at systems, cellular, and molecular levels for better understanding of the impact of climate change on epilepsy. Further focussed data would help us to develop evidence for mitigation methods to do more to protect people with epilepsy from the effects of climate change. (C) 2021 Elsevier Inc. All rights reserved. Show less
