Clinical behaviour of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) varies strikingly, both in terms of symptoms and outcome. An understanding of the basic biology unique to GEP-NETs is... Show moreClinical behaviour of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) varies strikingly, both in terms of symptoms and outcome. An understanding of the basic biology unique to GEP-NETs is necessary for optimum management of patients with these complex tumors. Although markers for GEP-NETs exist, sensitive and specific markers that predict tumor growth and behaviour are lacking. The general purpose of the studies described in this thesis was to investigate the epidemiology, diagnosis and pathogenesis of GEP-NETs in The Netherlands, to reveal insights in the pathological mechanisms contributing to the development and progression of these tumors. Not only worldwide but also in The Netherlands, the incidence of these tumors is increasing. The diverse studies contribute to a better understanding of the role of angiogenesis, neuropeptides and matrix metallo-proteinases in neuroendocrine tumors of the digestive tract and pancreas. Additional studies and further research will possible lead to new diagnostic and therapeutic implications of endoglin, bombesin and MMPs in patients with gastroenteropancreatic neuroendocrine tumors. Show less
