Throughout northern Europe, thousands of burial mounds were erected in the third millennium BCE. Starting in the Corded Ware culture, individual people were being buried underneath these mounds,... Show moreThroughout northern Europe, thousands of burial mounds were erected in the third millennium BCE. Starting in the Corded Ware culture, individual people were being buried underneath these mounds, often equipped with an almost rigid set of grave goods. This practice continued in the second half of the third millennium BCE with the start of the Bell Beaker phenomenon. In large parts of Europe, a ‘typical’ set of objects was placed in graves, known as the ‘Bell Beaker package’. This book focusses on the significance and meaning of these Late Neolithic graves. Why were people buried in a seemingly standardized manner, what did this signify and what does this reveal about these individuals, their role in society, their cultural identity and the people that buried them? By performing in-depth analyses of all the individual grave goods from Dutch graves, which includes use-wear analysis and experiments, the biography of grave goods is explored. How were they made, used and discarded? Subsequently the nature of these graves themselves are explored as contexts of deposition, and how these are part of a much wider ‘sacrificial landscape’. A novel and comprehensive interpretation is presented that shows how the objects from graves were connected with travel, drinking ceremonies and maintaining long-distance relationships. Show less
A family history of breast cancer is one of the most important risk factors for the disease. Over the last decades many genetic loci associated with breast cancer risk have been discovered. In... Show moreA family history of breast cancer is one of the most important risk factors for the disease. Over the last decades many genetic loci associated with breast cancer risk have been discovered. In spite of this, only approximately half of the familial relative risk (FRR) for breast cancer can be explained by the currently known genetic risk factor. In this thesis we have explored the role of rare genetic variants in familial breast cancer with the help of next generation sequencing. Through this approach we have not been able to identify any novel high-risk breast cancer susceptibility alleles. Although there are likely still several extremely rare risk alleles to be discovered and the presence of high-risk alleles outside of protein-coding regions cannot be excluded, it seems presently unlikely that these will explain a substantial proportion of familial breast cancer. Both our work and that of others has suggested that most non BRCA1/2 familial breast cancer cases are likely explained by a combination of low-, and moderate-risk susceptibility alleles. Show less
In this thesis we aim at automating the analysis of 3D echocardiography, mainly targeting the functional analysis of the left ventricle. Manual analysis of these data is cumbersome, time-consuming... Show moreIn this thesis we aim at automating the analysis of 3D echocardiography, mainly targeting the functional analysis of the left ventricle. Manual analysis of these data is cumbersome, time-consuming and is associated with inter-observer and inter-institutional variability. Methods for reconstruction of 3D echocardiographic images from fast rotating ultrasound transducers is presented and methods for analysis of 3D echocardiography in general, using tracking, detection and model-based segmentation techniques to ultimately fully automatically segment the left ventricle for functional analysis. We show that reliable quantification of left ventricular volume and mitral valve displacement can be achieved using the presented techniques. Show less
This thesis presents the study of the possibilities of functional analysis on shell implements. Shell tools from the pre-Columbian sites of Anse à la Gourde and Morel, Guadeloupe were studied and... Show moreThis thesis presents the study of the possibilities of functional analysis on shell implements. Shell tools from the pre-Columbian sites of Anse à la Gourde and Morel, Guadeloupe were studied and interpreted based on archaeological, ethnographical, ethnohistorical and experimental data. In addition, flint and stone tools of both sites were analysed. In this thesis functional analysis is approached from an integral point of view in order to be able to reconstruct the past technological system. The results of the functional analysis of all artefact categories are presented as well as a reconstruction of the technological system in the pre-Columbian period. It is demonstrated how this integral approach provides the possibilities to shed light on the choices made in the past on tool use and the utilisation of different raw materials. Show less
The author of this meticulously researched work surveys the possibilities of functional analysis of shell implements. Her study of shell tools, as well as flint and stone tools, from the pre... Show moreThe author of this meticulously researched work surveys the possibilities of functional analysis of shell implements. Her study of shell tools, as well as flint and stone tools, from the pre-Columbian sites of Anse à la Gourde and Morel, Guadeloupe draws on archaeological, ethnographical,ethnohistorical and experimental data.The results of the functional analysis of all artifact categories are presented, as well as a reconstruction of the technological system in the pre-Columbian period. She demonstrates the value of this integral approach in shedding light on the choices made in the past on tool use and the utilisation of different raw materials Show less
